Efficacy of Antibiotics Used as an Adjunct in the Treatment of Peri-implant Mucositis and Peri-implantitis: A Systematic Review and Meta-analysis

Yu Wang, Chia Yu Chen, Panagiota G. Stathopoulou, Laurel K. Graham, Jonathan Korostoff, Ya Wei Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This systematic review aimed to assess the clinical efficacy of antibiotics when used as an adjunct in treating peri-implant diseases. Materials and Methods: A systematic search of papers published between January 1980 and March 2020 was conducted. Randomized clinical trials with at least 10 patients who had peri-implant diseases, treated with or without adjunctive antibiotics in combination with surgical or nonsurgical therapies, and with a minimum of at least 3 months of follow-up were included. Meta-analyses were conducted to analyze weighted mean differences in probing depth reduction, radiographic bone level gain, and odds ratio of treatment success. Results: From the 856 articles identified, 10 articles met the inclusion criteria and were selected. Of these, 7 articles were used for the meta-analysis. The adjunctive use of antibiotics in the treatment of peri-implant diseases yielded significantly greater probing depth reduction (weighted mean differences = 0.56 mm at 3 months, P =. 001; 0.77 mm at 6 months, P <. 00001; 0.92 mm at 12 months, P <. 00001), radiographic bone level gain (weighted mean differences = 0.64 mm, P =. 03), and treatment success (odds ratio = 1.74, P =. 04) compared to the same treatment without antibiotics.

Original languageEnglish (US)
Pages (from-to)235-249
Number of pages15
JournalInternational Journal of Oral and Maxillofacial Implants
Volume37
Issue number2
DOIs
StatePublished - 2022

Keywords

  • antibiotics
  • dental implant
  • meta-analysis
  • peri-implantitis
  • systematic review

ASJC Scopus subject areas

  • Oral Surgery

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