Efficacy and tolerability of olanzapine in the treatment of schizotypal personality disorder

Matcheri Keshavan, Mujeeb Shad, Paul Soloff, Nina Schooler

    Research output: Contribution to journalArticlepeer-review

    27 Scopus citations


    Background: Few treatment studies of schizotypal personality disorder (SPD) have investigated the new, atypical antipsychotic drugs. This study examined the efficacy and tolerability of olanzapine, an atypical antipsychotic drug, in a series of patients with DSM-IV diagnosed schizotypal personality disorder. Method: This was a 26-week, open-label study with flexible dose design in 11 subjects with a diagnosis of schizotypal personality disorder based on Structured Clinical Interview for DSM-IV (SCID) and Personality Disorder Examination (PDE Journal of Psychiatric Disorders 1 (1987) 1). Subjects were treated with a low dose (average 9.32 mg/day) of olanzapine. Psychopathology was assessed at baseline and at the end of the study and analyzed with last observation carried forward analysis. Results: Patients showed significant improvements in psychosis and depression ratings, as well as in overall functioning. Olanzapine was well tolerated, though significant weight gain was observed. Conclusion: This study provides preliminary data regarding olanzapine efficacy and tolerability in schizotypal personality disorder subjects. These data need to be confirmed in larger controlled clinical trials.

    Original languageEnglish (US)
    Pages (from-to)97-101
    Number of pages5
    JournalSchizophrenia Research
    Issue number1
    StatePublished - Nov 1 2004


    • Efficacy
    • Olanzapine
    • Schizotypal personality disorder
    • Tolerability

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry


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