Effects of withdrawal from chronic amphetamine intoxication on exploratory and stereotyped behaviors in the rat

Robert Hitzemann, L. F. Tseng, B. A. Hitzemann, S. Sampath-Khanna, H. H. Loh

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Rats were administered 3, 6, and 12 mg/kg of d-amphetamine s.c. twice daily on a weekly increasing staircase schedule. On days 1, 7, 14, and 28 after the last injection of amphetamine the animals were challenged with 1 and 3 mg/kg of d-amphetamine and their behavior was observed. The 7-, 14-, and 28-day withdrawn animals required less amphetamine than controls to induce stereotyped behaviors. However, it was found that withdrawn animals and control animals were equally sensitive to the effects of apomorphine. Reserpine pretreatment eliminated the differences between control and withdrawn animals. α-Methyl tyrosine pretreatment blocked the effects of 1 but not 3 mg/kg of d-amphetamine in the withdrawn animals. Possible chemical mechanisms underlying the change in amphetamine sensitivity in the withdrawn animals are discussed.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalPsychopharmacology
Volume54
Issue number3
DOIs
StatePublished - Jan 1977
Externally publishedYes

Fingerprint

Stereotyped Behavior
Exploratory Behavior
Amphetamine
Dextroamphetamine
Apomorphine
Reserpine
Tyrosine
Appointments and Schedules
Injections

Keywords

  • Amphetamine
  • Sensitizaton
  • Stereotyped behavior
  • Withdrawal

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of withdrawal from chronic amphetamine intoxication on exploratory and stereotyped behaviors in the rat. / Hitzemann, Robert; Tseng, L. F.; Hitzemann, B. A.; Sampath-Khanna, S.; Loh, H. H.

In: Psychopharmacology, Vol. 54, No. 3, 01.1977, p. 295-302.

Research output: Contribution to journalArticle

Hitzemann, Robert ; Tseng, L. F. ; Hitzemann, B. A. ; Sampath-Khanna, S. ; Loh, H. H. / Effects of withdrawal from chronic amphetamine intoxication on exploratory and stereotyped behaviors in the rat. In: Psychopharmacology. 1977 ; Vol. 54, No. 3. pp. 295-302.
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