Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

Bela F. Asztalos, Michael M. Swarbrick, Ernst J. Schaefer, Gerard E. Dallal, Katalin V. Horvath, Masumi Ai, Kimber L. Stanhope, Iselin Austrheim-Smith, Bruce Wolfe, Mohamed Ali, Peter J. Havel

Research output: Contribution to journalArticle

Abstract

Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were significantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, α-1 and α-2 levels were significantly lower. Over 1 year, significant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and pre β-1 levels were observed with significant increases of HDL-C and α-1 levels (all P <0.05). Changes of fat mass were correlated with those of LDL cholesterol (P = 0.018) and LCAT mass (P = 0.011), but not with CETP mass (P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass (P = 0.005) and α-1 level (P = 0.004). Changes of fasting plasma insulin concentrations were positively correlated with those of LCAT mass (P = 0.043) and inversely with changes of α-1 (P = 0.03) and α-2 (P = 0.05) concentrations.jlr These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients.

Original languageEnglish (US)
Pages (from-to)2405-2412
Number of pages8
JournalJournal of Lipid Research
Volume51
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Cardiovascular disease risk
  • Glucose homeostasis
  • High density lipoprotein particles
  • Lipoprotein metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Medicine(all)

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  • Cite this

    Asztalos, B. F., Swarbrick, M. M., Schaefer, E. J., Dallal, G. E., Horvath, K. V., Ai, M., Stanhope, K. L., Austrheim-Smith, I., Wolfe, B., Ali, M., & Havel, P. J. (2010). Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women. Journal of Lipid Research, 51(8), 2405-2412. https://doi.org/10.1194/jlr.P900015