Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus

Andrzej Szutowicz, Paul A. Srere, Charles N. Allen, Isaac L. Crawford

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Abstract: Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP‐citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the two enzymes in the cytosol (S3) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl‐CoA synthase, and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. The data indicate that ATP‐citrate lyase is linked to the septal‐hippocampal pathway and that the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.

Original languageEnglish (US)
Pages (from-to)458-463
Number of pages6
JournalJournal of neurochemistry
Issue number2
StatePublished - Aug 1982



  • ATP‐citrate lyase
  • Acetyl‐CoA
  • Choline acetyltransferase
  • Septal‐hippocampal pathway

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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