Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus

Andrzej Szutowicz, Paul A. Srere, Charles Allen, Isaac L. Crawford

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Abstract: Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP‐citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the two enzymes in the cytosol (S3) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl‐CoA synthase, and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. The data indicate that ATP‐citrate lyase is linked to the septal‐hippocampal pathway and that the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.

Original languageEnglish (US)
Pages (from-to)458-463
Number of pages6
JournalJournal of Neurochemistry
Volume39
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Lyases
Metabolism
Cholinergic Agents
Rats
Hippocampus
Carnitine O-Acetyltransferase
Septum of Brain
Citrate (si)-Synthase
Choline O-Acetyltransferase
Subcellular Fractions
Nerve Endings
Enzymes
Pyruvic Acid
Cytosol
Brain
Oxidoreductases

Keywords

  • Acetyl‐CoA
  • ATP‐citrate lyase
  • Choline acetyltransferase
  • Septal‐hippocampal pathway

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus. / Szutowicz, Andrzej; Srere, Paul A.; Allen, Charles; Crawford, Isaac L.

In: Journal of Neurochemistry, Vol. 39, No. 2, 1982, p. 458-463.

Research output: Contribution to journalArticle

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