Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus

Andrzej Szutowicz; Paul A. Srere; Charles N. Allen; Isaac L. Crawford

doi:10.1111/j.1471-4159.1982.tb03967.x

Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus

Andrzej Szutowicz, Paul A. Srere, Charles N. Allen, Isaac L. Crawford

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Abstract: Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP‐citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the two enzymes in the cytosol (S₃) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl‐CoA synthase, and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. The data indicate that ATP‐citrate lyase is linked to the septal‐hippocampal pathway and that the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.

Original language	English (US)
Pages (from-to)	458-463
Number of pages	6
Journal	Journal of neurochemistry
Volume	39
Issue number	2
DOIs	https://doi.org/10.1111/j.1471-4159.1982.tb03967.x
State	Published - Aug 1982
Externally published	Yes

Keywords

ATP‐citrate lyase
Acetyl‐CoA
Choline acetyltransferase
Septal‐hippocampal pathway

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1982.tb03967.x

Cite this

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title = "Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus",

abstract = "Abstract: Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP‐citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the two enzymes in the cytosol (S3) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl‐CoA synthase, and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. The data indicate that ATP‐citrate lyase is linked to the septal‐hippocampal pathway and that the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.",

keywords = "ATP‐citrate lyase, Acetyl‐CoA, Choline acetyltransferase, Septal‐hippocampal pathway",

author = "Andrzej Szutowicz and Srere, {Paul A.} and Allen, {Charles N.} and Crawford, {Isaac L.}",

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AU - Szutowicz, Andrzej

AU - Srere, Paul A.

AU - Allen, Charles N.

AU - Crawford, Isaac L.

PY - 1982/8

Y1 - 1982/8

N2 - Abstract: Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP‐citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the two enzymes in the cytosol (S3) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl‐CoA synthase, and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. The data indicate that ATP‐citrate lyase is linked to the septal‐hippocampal pathway and that the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.

AB - Abstract: Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP‐citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the two enzymes in the cytosol (S3) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl‐CoA synthase, and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. The data indicate that ATP‐citrate lyase is linked to the septal‐hippocampal pathway and that the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.

KW - ATP‐citrate lyase

KW - Acetyl‐CoA

KW - Choline acetyltransferase

KW - Septal‐hippocampal pathway

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Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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