Effects of proteasome inhibitor PSI on neoplastic and non-transformed cell lines

E. Pleban, M. Bury, I. Mlynarczuk, Cezary Wojcik

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Abstract

In this study we compared the sensitivity of different human and murine cell lines varying in the stage of transformation to dose- and time-dependent cytostatic and/or cytotoxic effects of PSI (a selective proteasome inhibitor), measured by a standard MTT assay. It was found that intensively proliferating cell lines were more sensitive to very small doses of PSI after 24 h incubation than the slow proliferating ones. Non-transformed cell lines showed no sensitivity to PSI, as there was no difference in cell viability in comparison with the control group even after 72 h incubation.

Original languageEnglish (US)
Pages (from-to)133-134
Number of pages2
JournalFolia Histochemica et Cytobiologica
Volume39
Issue number2
Publication statusPublished - 2001
Externally publishedYes

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Keywords

  • Cell culture
  • MTT assay
  • Proteasome
  • PSI

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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