Effects of perilymphatic perfusion with neomycin on the cochlear microphonic potential in the Guinea pig

A. L. Nuttall; D. M. Marques; M. Lawrence

doi:10.3109/00016487709128863

Effects of perilymphatic perfusion with neomycin on the cochlear microphonic potential in the Guinea pig

A. L. Nuttall, D. M. Marques, M. Lawrence

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

The effects of three concentrations of neomy-cin, administered by a method of acute perilymphatic per-fusion of the guinea pig cochlea, on the cochlear micro-phonic potential (CM) at 4 kHz and 500 Hz are described. A concentration-dependent reduction in CM occurred during the 60 minute perfusion period. Neomycin at 10-⁴ M did not change the CM magnitude, while at 10-³ and 10-² M it caused 4 kHz (and 500 Hz) CM reductions which began within 24 (for both frequencies) minutes and 10 (and 12) minutes of drug application respectively. CM reduction proceeded at a higher rate for greater neomycin concentration. The perfusion technique, the implication of the frequency indifference, and the potential of the perfusion technique for inner ear biochemical analysis are discussed.

Original language	English (US)
Pages (from-to)	393-400
Number of pages	8
Journal	Acta Oto-Laryngologica
Volume	83
Issue number	1-6
DOIs	https://doi.org/10.3109/00016487709128863
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.3109/00016487709128863

Cite this

@article{b40786f4165f4c72a645bea2924e33fa,

title = "Effects of perilymphatic perfusion with neomycin on the cochlear microphonic potential in the Guinea pig",

abstract = "The effects of three concentrations of neomy-cin, administered by a method of acute perilymphatic per-fusion of the guinea pig cochlea, on the cochlear micro-phonic potential (CM) at 4 kHz and 500 Hz are described. A concentration-dependent reduction in CM occurred during the 60 minute perfusion period. Neomycin at 10-4 M did not change the CM magnitude, while at 10-3 and 10-2 M it caused 4 kHz (and 500 Hz) CM reductions which began within 24 (for both frequencies) minutes and 10 (and 12) minutes of drug application respectively. CM reduction proceeded at a higher rate for greater neomycin concentration. The perfusion technique, the implication of the frequency indifference, and the potential of the perfusion technique for inner ear biochemical analysis are discussed.",

author = "Nuttall, {A. L.} and Marques, {D. M.} and M. Lawrence",

note = "Funding Information: This study was presented in part at the 89th meeting of the Acoustical Society of America in Austin Texas, April 1975. It was supported by Public Health Service Program Project Grant 05785 and NS 1173 1.",

year = "1977",

doi = "10.3109/00016487709128863",

language = "English (US)",

volume = "83",

pages = "393--400",

journal = "Acta Oto-Laryngologica",

issn = "0001-6489",

publisher = "Informa Healthcare",

number = "1-6",

}

TY - JOUR

T1 - Effects of perilymphatic perfusion with neomycin on the cochlear microphonic potential in the Guinea pig

AU - Nuttall, A. L.

AU - Marques, D. M.

AU - Lawrence, M.

N1 - Funding Information: This study was presented in part at the 89th meeting of the Acoustical Society of America in Austin Texas, April 1975. It was supported by Public Health Service Program Project Grant 05785 and NS 1173 1.

PY - 1977

Y1 - 1977

N2 - The effects of three concentrations of neomy-cin, administered by a method of acute perilymphatic per-fusion of the guinea pig cochlea, on the cochlear micro-phonic potential (CM) at 4 kHz and 500 Hz are described. A concentration-dependent reduction in CM occurred during the 60 minute perfusion period. Neomycin at 10-4 M did not change the CM magnitude, while at 10-3 and 10-2 M it caused 4 kHz (and 500 Hz) CM reductions which began within 24 (for both frequencies) minutes and 10 (and 12) minutes of drug application respectively. CM reduction proceeded at a higher rate for greater neomycin concentration. The perfusion technique, the implication of the frequency indifference, and the potential of the perfusion technique for inner ear biochemical analysis are discussed.

AB - The effects of three concentrations of neomy-cin, administered by a method of acute perilymphatic per-fusion of the guinea pig cochlea, on the cochlear micro-phonic potential (CM) at 4 kHz and 500 Hz are described. A concentration-dependent reduction in CM occurred during the 60 minute perfusion period. Neomycin at 10-4 M did not change the CM magnitude, while at 10-3 and 10-2 M it caused 4 kHz (and 500 Hz) CM reductions which began within 24 (for both frequencies) minutes and 10 (and 12) minutes of drug application respectively. CM reduction proceeded at a higher rate for greater neomycin concentration. The perfusion technique, the implication of the frequency indifference, and the potential of the perfusion technique for inner ear biochemical analysis are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0017645661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017645661&partnerID=8YFLogxK

U2 - 10.3109/00016487709128863

DO - 10.3109/00016487709128863

M3 - Article

C2 - 888674

AN - SCOPUS:0017645661

SN - 0001-6489

VL - 83

SP - 393

EP - 400

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 1-6

ER -

Effects of perilymphatic perfusion with neomycin on the cochlear microphonic potential in the Guinea pig

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this