Effects of meternal and long-term postnatal protein malnutrition on brain size and composition in rhesus monkeys

O. W. Portman, Martha Neuringer, M. Alexander

    Research output: Contribution to journalArticle

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    Abstract

    Rhesus monkeys consumed purified diets that supplied either low or adequate levels of protein (3.8 vs. 13.9% of energy as casein) from birth until approximately 10 yr of age. A subgroup (PN) was born of mothers that also received low or control levels of protein throughout pregnancy. The deprived groups weighed significantly less than corresponding control groups. Weights of the total brain, cerebellum and brain stem were significantly reduced in the PN deprived group. Analysis of variance also indicated that low protein diets produced a significant reduction in cerebral weight. The concentrations of DNA, protein and eight different lipids from seven different sites in the central peripheral nervous system were not greatly affected by diet. The total content of lecithin and phosphatidylethanolamine was significantly depressed in some parts of the deprived monkey brains. The deficits in brain weight of the PN group (10% for the cerebrum, 13% for the cerebellum and 18% for the brain stem) were very similar to those observed previously in 1-mo-old monkeys born of protein-deprived mothers and fed low protein diets postnatally. On the other hand, monkeys born of adequately nourished mothers and then fed low protein diets from birth up to 12 yr showed no deficit in brain weight despite reduction in body weight to less than half of control values.

    Original languageEnglish (US)
    Pages (from-to)1844-1851
    Number of pages8
    JournalJournal of Nutrition
    Volume117
    Issue number11
    StatePublished - 1987

    Fingerprint

    kwashiorkor
    Macaca mulatta
    Malnutrition
    Protein-Restricted Diet
    low protein diet
    Haplorhini
    monkeys
    brain
    Brain
    brain stem
    cerebellum
    Weights and Measures
    Cerebellum
    Brain Stem
    Proteins
    Parturition
    Pregnancy Proteins
    Diet
    cerebrum
    peripheral nervous system

    ASJC Scopus subject areas

    • Food Science
    • Medicine (miscellaneous)

    Cite this

    Effects of meternal and long-term postnatal protein malnutrition on brain size and composition in rhesus monkeys. / Portman, O. W.; Neuringer, Martha; Alexander, M.

    In: Journal of Nutrition, Vol. 117, No. 11, 1987, p. 1844-1851.

    Research output: Contribution to journalArticle

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