Effects of melatonin and propranolol on sleep of the rat

Wallace B. Mendelson; J. Christian Gillin; Susan D. Dawson; Alfred J. Lewy; Richard Jed Wyatt

doi:10.1016/0006-8993(80)90793-3

Effects of melatonin and propranolol on sleep of the rat

Wallace B. Mendelson, J. Christian Gillin, Susan D. Dawson, Alfred J. Lewy, Richard Jed Wyatt

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.

Original language	English (US)
Pages (from-to)	240-244
Number of pages	5
Journal	Brain research
Volume	201
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(80)90793-3
State	Published - Nov 10 1980
Externally published	Yes

Keywords

REM sleep
l-propranolol
melatonin
sleep

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(80)90793-3

Cite this

@article{69b9f6e4bfd144fd80a7b6ce5893bb5d,

title = "Effects of melatonin and propranolol on sleep of the rat",

abstract = "Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.",

keywords = "REM sleep, l-propranolol, melatonin, sleep",

author = "Mendelson, {Wallace B.} and Gillin, {J. Christian} and Dawson, {Susan D.} and Lewy, {Alfred J.} and Wyatt, {Richard Jed}",

year = "1980",

month = nov,

day = "10",

doi = "10.1016/0006-8993(80)90793-3",

language = "English (US)",

volume = "201",

pages = "240--244",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Effects of melatonin and propranolol on sleep of the rat

AU - Mendelson, Wallace B.

AU - Gillin, J. Christian

AU - Dawson, Susan D.

AU - Lewy, Alfred J.

AU - Wyatt, Richard Jed

PY - 1980/11/10

Y1 - 1980/11/10

N2 - Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.

AB - Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.

KW - REM sleep

KW - l-propranolol

KW - melatonin

KW - sleep

UR - http://www.scopus.com/inward/record.url?scp=0018974921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018974921&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(80)90793-3

DO - 10.1016/0006-8993(80)90793-3

M3 - Article

C2 - 7417837

AN - SCOPUS:0018974921

SN - 0006-8993

VL - 201

SP - 240

EP - 244

JO - Brain research

JF - Brain research

IS - 1

ER -

Effects of melatonin and propranolol on sleep of the rat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this