Effects of melatonin and propranolol on sleep of the rat

Wallace B. Mendelson, J. Christian Gillin, Susan D. Dawson, Alfred J. Lewy, Richard Jed Wyatt

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70 Scopus citations


Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.

Original languageEnglish (US)
Pages (from-to)240-244
Number of pages5
JournalBrain research
Issue number1
StatePublished - Nov 10 1980


  • REM sleep
  • l-propranolol
  • melatonin
  • sleep

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Mendelson, W. B., Gillin, J. C., Dawson, S. D., Lewy, A. J., & Wyatt, R. J. (1980). Effects of melatonin and propranolol on sleep of the rat. Brain research, 201(1), 240-244. https://doi.org/10.1016/0006-8993(80)90793-3