Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis

Joshua D. George; Edward Kim; Rebecca Spain; Dennis Bourdette; Sonemany Salinthone

doi:10.1016/j.jneuroim.2017.12.009

Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis

Joshua D. George, Edward Kim, Rebecca Spain, Dennis Bourdette, Sonemany Salinthone

Neurology

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.

Original language	English (US)
Pages (from-to)	24-27
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	315
DOIs	https://doi.org/10.1016/j.jneuroim.2017.12.009
State	Published - Feb 15 2018

Keywords

B cell
Lipoic acid
Migration
Monocyte
RRMS

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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George, J. D., Kim, E., Spain, R., Bourdette, D., & Salinthone, S. (2018). Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis. Journal of Neuroimmunology, 315, 24-27. https://doi.org/10.1016/j.jneuroim.2017.12.009

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abstract = "Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.",

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AB - Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.

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