Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis

Joshua D. George; Edward Kim; Rebecca Spain; Dennis Bourdette; Sonemany Salinthone

doi:10.1016/j.jneuroim.2017.12.009

Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis

Joshua D. George, Edward Kim, Rebecca Spain, Dennis Bourdette, Sonemany Salinthone

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.

Original language	English (US)
Pages (from-to)	24-27
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	315
DOIs	https://doi.org/10.1016/j.jneuroim.2017.12.009
State	Published - Feb 15 2018
Externally published	Yes

Keywords

B cell
Lipoic acid
Migration
Monocyte
RRMS

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2017.12.009

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Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis. / George, Joshua D.; Kim, Edward ; Spain, Rebecca ; Bourdette, Dennis; Salinthone, Sonemany.

In: Journal of Neuroimmunology, Vol. 315, 15.02.2018, p. 24-27.

Research output: Contribution to journal › Article › peer-review

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abstract = "Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.",

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AU - Salinthone, Sonemany

N1 - Funding Information: We would like to thank Sarah Fiedler for her help editing and general guidance. This work was supported by a Biomedical Laboratory Research and Development Service Merit Review ( 1I01BX001793 ), from the United States Department of Veterans Affairs. Oregon Clinical and Translational Institute (OCTRI) provided clinical coordination and nursing services with the support of National Institutes of Health (NIH) grant UL1TR000128 from the National Center for Advancing Translational Sciences (NCATS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: © 2017

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AB - Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.

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Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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