Abstract
Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 24-27 |
| Number of pages | 4 |
| Journal | Journal of Neuroimmunology |
| Volume | 315 |
| DOIs | |
| State | Published - Feb 15 2018 |
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Keywords
- B cell
- Lipoic acid
- Migration
- Monocyte
- RRMS
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
Cite this
Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis. / George, Joshua D.; Kim, Edward; Spain, Rebecca; Bourdette, Dennis; Salinthone, Sonemany.
In: Journal of Neuroimmunology, Vol. 315, 15.02.2018, p. 24-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis
AU - George, Joshua D.
AU - Kim, Edward
AU - Spain, Rebecca
AU - Bourdette, Dennis
AU - Salinthone, Sonemany
PY - 2018/2/15
Y1 - 2018/2/15
N2 - Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.
AB - Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.
KW - B cell
KW - Lipoic acid
KW - Migration
KW - Monocyte
KW - RRMS
UR - http://www.scopus.com/inward/record.url?scp=85039758996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039758996&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2017.12.009
DO - 10.1016/j.jneuroim.2017.12.009
M3 - Article
AN - SCOPUS:85039758996
VL - 315
SP - 24
EP - 27
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -