Abstract
The effects of graded doses of dobutamine on renal function were studied in eight male volunteers. The infusion rates were 2.5, 5 and 10 μg/kg/min. Systolic blood pressure increased by 19% (P<0.01), 31% (P<0.01), and 44% (P<0.01), respectively, while diastolic blood pressure decreased by 17% (P<0.02), 17% (P<0.02) and 25% (P<0.01), respectively. Heart rate increased at the highest dosage by 32%, (P<0.01). Glomerular filtration rate (GFR) diminished at all three infusion speeds by 10% (P<0.02), 9% (P<0.05) and 14% (P<0.02), respectively, while renal blood flow (RBF) was unchanged. Urine flow rate (UF) decreased by 36% (P<0.05) and fractional free water clearance (CH2O/CIn) diminished by 37% (P<0.05) at the rate of 10 μg/kg/min. Fractional potassium excretion (CK/Cin) decreased by 34% (P<0.01) and 44% (P<0.01) at the two highest rates. Fractional sodium excretion (CNa/CIn) and fractional chloride excretion (CCl/CIn) were unchanged. Catecholamine levels were unaltered. Plasma renin activity (PRA) rose significantly (P<0.05) at the highest infusion rate of dobutamine. It is concluded that dobutamine influences GFR, the clinical significance of which, however, is difficult to evaluate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 72-75 |
| Number of pages | 4 |
| Journal | Acta Anaesthesiologica Scandinavica |
| Volume | 30 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1986 |
| Externally published | Yes |
Keywords
- Catecholamines
- dobutamine
- electrolyte excretion
- glomerular filtration rate
- plasma renin activity
- renal function
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine