Effects of dobutamine on renal function in normal man

L. Westman, Per-Olof Järnberg

Research output: Contribution to journalArticle

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Abstract

The effects of graded doses of dobutamine on renal function were studied in eight male volunteers. The infusion rates were 2.5, 5 and 10 μg/kg/min. Systolic blood pressure increased by 19% (P <0.01), 31% (P <0.01), and 44% (P <0.01), respectively, while diastolic blood pressure decreased by 17% (P <0.02), 17% (P <0.02) and 25% (P <0.01), respectively. Heart rate increased at the highest dosage by 32% (P <0.01). Glomerular filtration rate (GFR) diminished at all three infusion speeds by 10% (P <0.02), 9% (P <0.05) and 14% (P <0.02), respectively, while renal blood flow (RBF) was unchanged. Urine flow rate (UF) decreased by 36% (P <0.05) and fractional free water clearance (CH2O/C(In)) diminished by 37% (P <0.05) at the rate of 10 μg/kg/min. Fractional potassium excretion (C(K)/C(In)) decreased by 34% (P <0.01) and 44% (P <0.01) at the two highest rates. Fractional sodium excretion (C(Na)/C(In)) and fractional chloride excretion (C(Cl)/C(In)) were unchanged. Catecholamine levels were unaltered. Plasma renin activity (PRA) rose significantly (P <0.05) at the highest infusion rate of dobutamine. It is concluded that dobutamine influences GFR, the clinical significance of which, however, is difficult to evaluate.

Original languageEnglish (US)
Pages (from-to)72-75
Number of pages4
JournalActa Anaesthesiologica Scandinavica
Volume30
Issue number1
StatePublished - 1986
Externally publishedYes

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Dobutamine
Blood Pressure
Kidney
Glomerular Filtration Rate
Renal Circulation
Renin
Catecholamines
Chlorides
Volunteers
Potassium
Heart Rate
Sodium
Urine
Water

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Effects of dobutamine on renal function in normal man. / Westman, L.; Järnberg, Per-Olof.

In: Acta Anaesthesiologica Scandinavica, Vol. 30, No. 1, 1986, p. 72-75.

Research output: Contribution to journalArticle

Westman, L & Järnberg, P-O 1986, 'Effects of dobutamine on renal function in normal man', Acta Anaesthesiologica Scandinavica, vol. 30, no. 1, pp. 72-75.
Westman, L. ; Järnberg, Per-Olof. / Effects of dobutamine on renal function in normal man. In: Acta Anaesthesiologica Scandinavica. 1986 ; Vol. 30, No. 1. pp. 72-75.
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