Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis)

Carol A. Shively, Joseph E. Mietus, Kathleen (Kathy) Grant, Ary L. Goldberger, Allyson J. Bennett, Stephanie L. Willard

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Rationale: The effects of chronic moderate alcohol consumption on cardiac function are not understood. Acute stress may affect cardiac function by shifting autonomic cardiac regulation in favor of the sympathetic nervous system. Although alcohol consumption often increases at times of stress, the interactive effects of stress and chronic moderate alcohol consumption on cardiac regulation have not been studied. Objectives and methods: The objective was to assess the effects of long-term (1-2 years) moderate (a two-drink/day equivalent, 5 days/week) alcohol consumption on heart rate (HR) variability under normal and acutely stressful conditions in small stable groups of ovariectomized adult cynomolgus monkeys (Macaca fascicularis). Monkeys were trained to voluntarily drink their daily alcohol dose (

    Original languageEnglish (US)
    Pages (from-to)183-191
    Number of pages9
    JournalPsychopharmacology
    Volume192
    Issue number2
    DOIs
    StatePublished - Jun 2007

    Fingerprint

    Macaca fascicularis
    Alcohol Drinking
    Primates
    Heart Rate
    Sympathetic Nervous System
    Haplorhini
    Alcohols

    Keywords

    • Alcohol
    • Females
    • Heart rate variability
    • Monkeys
    • Spectral analysis
    • Stress

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis). / Shively, Carol A.; Mietus, Joseph E.; Grant, Kathleen (Kathy); Goldberger, Ary L.; Bennett, Allyson J.; Willard, Stephanie L.

    In: Psychopharmacology, Vol. 192, No. 2, 06.2007, p. 183-191.

    Research output: Contribution to journalArticle

    Shively, Carol A. ; Mietus, Joseph E. ; Grant, Kathleen (Kathy) ; Goldberger, Ary L. ; Bennett, Allyson J. ; Willard, Stephanie L. / Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis). In: Psychopharmacology. 2007 ; Vol. 192, No. 2. pp. 183-191.
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