Effects of blood flow and/or ventilation restriction on radiofrequency coagulation size in the lung: An experimental study in swine

Hiroshi Anai, Barry Uchida, Dusan Pavcnik, Chang Kyu Seong, Phillip Baker, Luiz Otavio Correa, Christopher Corless, Serdar Geyik, Kivilcim Yavuz, Hiroshi Sakaguchi, Kimihiko Kichikawa, Frederick Keller, Josef Rosch

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The purpose of this study was to investigate how the restriction of blood flow and/or ventilation affects the radiofrequency (RF) ablation coagulation size in lung parenchyma. Thirty-one RF ablations were done in 16 normal lungs of 8 living swine with 2-cm LeVeen needles. Eight RF ablations were performed as a control (group G1), eight with balloon occlusion of the ipsilateral mainstem bronchus (G2), eight with occlusion of the ipsilateral pulmonary artery (G3), and seven with occlusion of both the ipsilateral bronchus and pulmonary artery (G4). Coagulation diameters and volumes of each ablation zone were compared on computed tomography (CT) and gross specimen examinations. Twenty-six coagulation zones were suitable for evaluation: eight in G1, five in G2, seven in G3, and six in G4 groups. In G1, the mean coagulation diameter was 21.5 ± 3.5 mm on CT and 19.5 ± 1.78 mm on gross specimen examination. In G2, the mean diameters were 26.5 ± 5.1 mm and 23.0 ± 2.7 mm on CT and gross specimen examination, respectively. In G3, the mean diameters were 29.4 ± 2.2 mm and 27.4 ± 2.9 mm on CT and gross specimen examination, respectively, and in G4, they were 32.6 ± 3.33 mm and 28.8 ± 2.6 mm, respectively. The mean coagulation volumes were 3.39 ± l.52 cm 3 on CT and 3.01 ± 0.94 cm3 on gross examinations in G1, 6.56 ± 2.47 cm3 and 5.22 ± 0.85 cm3 in G2, 10.93 ± 2.17 cm3 and 9.97 ± 2.91 cm3 in G3, and 13.81 ± 3.03 cm3 and 11.06 ± 3.27 cm 3 in G4, respectively. The mean coagulation diameters on gross examination and mean coagulation volumes on CT and gross examination with G3 and G4 were significantly larger than those in G1 (p <0.0001, p <0.0001, p <0.0001, respectively) or in G2 (p <0.05, p <0.005, p <0.005, respectively). Pulmonary collapse occurred in one lung in G2 and pulmonary artery thrombus in two lungs of G3 and two lungs of G4. The coagulation size of RF ablation of the lung parenchyma is increased by ventilation and particularly by pulmonary artery blood flow restriction. The value of these restrictions for potential clinical use needs to be explored in experimentally induced lung tumors.

Original languageEnglish (US)
Pages (from-to)838-845
Number of pages8
JournalCardioVascular and Interventional Radiology
Volume29
Issue number5
DOIs
StatePublished - Oct 2006

Fingerprint

Ventilation
Swine
Lung
Tomography
Pulmonary Artery
Bronchi
Balloon Occlusion
Cone-Beam Computed Tomography
Pulmonary Atelectasis
Needles
Thrombosis
Control Groups
Neoplasms

Keywords

  • Animals
  • Experimental study
  • Lung
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of blood flow and/or ventilation restriction on radiofrequency coagulation size in the lung : An experimental study in swine. / Anai, Hiroshi; Uchida, Barry; Pavcnik, Dusan; Seong, Chang Kyu; Baker, Phillip; Correa, Luiz Otavio; Corless, Christopher; Geyik, Serdar; Yavuz, Kivilcim; Sakaguchi, Hiroshi; Kichikawa, Kimihiko; Keller, Frederick; Rosch, Josef.

In: CardioVascular and Interventional Radiology, Vol. 29, No. 5, 10.2006, p. 838-845.

Research output: Contribution to journalArticle

Anai, Hiroshi ; Uchida, Barry ; Pavcnik, Dusan ; Seong, Chang Kyu ; Baker, Phillip ; Correa, Luiz Otavio ; Corless, Christopher ; Geyik, Serdar ; Yavuz, Kivilcim ; Sakaguchi, Hiroshi ; Kichikawa, Kimihiko ; Keller, Frederick ; Rosch, Josef. / Effects of blood flow and/or ventilation restriction on radiofrequency coagulation size in the lung : An experimental study in swine. In: CardioVascular and Interventional Radiology. 2006 ; Vol. 29, No. 5. pp. 838-845.
@article{ace0e2477fe04daaac03b6f2e030834b,
title = "Effects of blood flow and/or ventilation restriction on radiofrequency coagulation size in the lung: An experimental study in swine",
abstract = "The purpose of this study was to investigate how the restriction of blood flow and/or ventilation affects the radiofrequency (RF) ablation coagulation size in lung parenchyma. Thirty-one RF ablations were done in 16 normal lungs of 8 living swine with 2-cm LeVeen needles. Eight RF ablations were performed as a control (group G1), eight with balloon occlusion of the ipsilateral mainstem bronchus (G2), eight with occlusion of the ipsilateral pulmonary artery (G3), and seven with occlusion of both the ipsilateral bronchus and pulmonary artery (G4). Coagulation diameters and volumes of each ablation zone were compared on computed tomography (CT) and gross specimen examinations. Twenty-six coagulation zones were suitable for evaluation: eight in G1, five in G2, seven in G3, and six in G4 groups. In G1, the mean coagulation diameter was 21.5 ± 3.5 mm on CT and 19.5 ± 1.78 mm on gross specimen examination. In G2, the mean diameters were 26.5 ± 5.1 mm and 23.0 ± 2.7 mm on CT and gross specimen examination, respectively. In G3, the mean diameters were 29.4 ± 2.2 mm and 27.4 ± 2.9 mm on CT and gross specimen examination, respectively, and in G4, they were 32.6 ± 3.33 mm and 28.8 ± 2.6 mm, respectively. The mean coagulation volumes were 3.39 ± l.52 cm 3 on CT and 3.01 ± 0.94 cm3 on gross examinations in G1, 6.56 ± 2.47 cm3 and 5.22 ± 0.85 cm3 in G2, 10.93 ± 2.17 cm3 and 9.97 ± 2.91 cm3 in G3, and 13.81 ± 3.03 cm3 and 11.06 ± 3.27 cm 3 in G4, respectively. The mean coagulation diameters on gross examination and mean coagulation volumes on CT and gross examination with G3 and G4 were significantly larger than those in G1 (p <0.0001, p <0.0001, p <0.0001, respectively) or in G2 (p <0.05, p <0.005, p <0.005, respectively). Pulmonary collapse occurred in one lung in G2 and pulmonary artery thrombus in two lungs of G3 and two lungs of G4. The coagulation size of RF ablation of the lung parenchyma is increased by ventilation and particularly by pulmonary artery blood flow restriction. The value of these restrictions for potential clinical use needs to be explored in experimentally induced lung tumors.",
keywords = "Animals, Experimental study, Lung, Radiofrequency (RF) ablation",
author = "Hiroshi Anai and Barry Uchida and Dusan Pavcnik and Seong, {Chang Kyu} and Phillip Baker and Correa, {Luiz Otavio} and Christopher Corless and Serdar Geyik and Kivilcim Yavuz and Hiroshi Sakaguchi and Kimihiko Kichikawa and Frederick Keller and Josef Rosch",
year = "2006",
month = "10",
doi = "10.1007/s00270-005-0217-7",
language = "English (US)",
volume = "29",
pages = "838--845",
journal = "CardioVascular and Interventional Radiology",
issn = "7415-5101",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Effects of blood flow and/or ventilation restriction on radiofrequency coagulation size in the lung

T2 - An experimental study in swine

AU - Anai, Hiroshi

AU - Uchida, Barry

AU - Pavcnik, Dusan

AU - Seong, Chang Kyu

AU - Baker, Phillip

AU - Correa, Luiz Otavio

AU - Corless, Christopher

AU - Geyik, Serdar

AU - Yavuz, Kivilcim

AU - Sakaguchi, Hiroshi

AU - Kichikawa, Kimihiko

AU - Keller, Frederick

AU - Rosch, Josef

PY - 2006/10

Y1 - 2006/10

N2 - The purpose of this study was to investigate how the restriction of blood flow and/or ventilation affects the radiofrequency (RF) ablation coagulation size in lung parenchyma. Thirty-one RF ablations were done in 16 normal lungs of 8 living swine with 2-cm LeVeen needles. Eight RF ablations were performed as a control (group G1), eight with balloon occlusion of the ipsilateral mainstem bronchus (G2), eight with occlusion of the ipsilateral pulmonary artery (G3), and seven with occlusion of both the ipsilateral bronchus and pulmonary artery (G4). Coagulation diameters and volumes of each ablation zone were compared on computed tomography (CT) and gross specimen examinations. Twenty-six coagulation zones were suitable for evaluation: eight in G1, five in G2, seven in G3, and six in G4 groups. In G1, the mean coagulation diameter was 21.5 ± 3.5 mm on CT and 19.5 ± 1.78 mm on gross specimen examination. In G2, the mean diameters were 26.5 ± 5.1 mm and 23.0 ± 2.7 mm on CT and gross specimen examination, respectively. In G3, the mean diameters were 29.4 ± 2.2 mm and 27.4 ± 2.9 mm on CT and gross specimen examination, respectively, and in G4, they were 32.6 ± 3.33 mm and 28.8 ± 2.6 mm, respectively. The mean coagulation volumes were 3.39 ± l.52 cm 3 on CT and 3.01 ± 0.94 cm3 on gross examinations in G1, 6.56 ± 2.47 cm3 and 5.22 ± 0.85 cm3 in G2, 10.93 ± 2.17 cm3 and 9.97 ± 2.91 cm3 in G3, and 13.81 ± 3.03 cm3 and 11.06 ± 3.27 cm 3 in G4, respectively. The mean coagulation diameters on gross examination and mean coagulation volumes on CT and gross examination with G3 and G4 were significantly larger than those in G1 (p <0.0001, p <0.0001, p <0.0001, respectively) or in G2 (p <0.05, p <0.005, p <0.005, respectively). Pulmonary collapse occurred in one lung in G2 and pulmonary artery thrombus in two lungs of G3 and two lungs of G4. The coagulation size of RF ablation of the lung parenchyma is increased by ventilation and particularly by pulmonary artery blood flow restriction. The value of these restrictions for potential clinical use needs to be explored in experimentally induced lung tumors.

AB - The purpose of this study was to investigate how the restriction of blood flow and/or ventilation affects the radiofrequency (RF) ablation coagulation size in lung parenchyma. Thirty-one RF ablations were done in 16 normal lungs of 8 living swine with 2-cm LeVeen needles. Eight RF ablations were performed as a control (group G1), eight with balloon occlusion of the ipsilateral mainstem bronchus (G2), eight with occlusion of the ipsilateral pulmonary artery (G3), and seven with occlusion of both the ipsilateral bronchus and pulmonary artery (G4). Coagulation diameters and volumes of each ablation zone were compared on computed tomography (CT) and gross specimen examinations. Twenty-six coagulation zones were suitable for evaluation: eight in G1, five in G2, seven in G3, and six in G4 groups. In G1, the mean coagulation diameter was 21.5 ± 3.5 mm on CT and 19.5 ± 1.78 mm on gross specimen examination. In G2, the mean diameters were 26.5 ± 5.1 mm and 23.0 ± 2.7 mm on CT and gross specimen examination, respectively. In G3, the mean diameters were 29.4 ± 2.2 mm and 27.4 ± 2.9 mm on CT and gross specimen examination, respectively, and in G4, they were 32.6 ± 3.33 mm and 28.8 ± 2.6 mm, respectively. The mean coagulation volumes were 3.39 ± l.52 cm 3 on CT and 3.01 ± 0.94 cm3 on gross examinations in G1, 6.56 ± 2.47 cm3 and 5.22 ± 0.85 cm3 in G2, 10.93 ± 2.17 cm3 and 9.97 ± 2.91 cm3 in G3, and 13.81 ± 3.03 cm3 and 11.06 ± 3.27 cm 3 in G4, respectively. The mean coagulation diameters on gross examination and mean coagulation volumes on CT and gross examination with G3 and G4 were significantly larger than those in G1 (p <0.0001, p <0.0001, p <0.0001, respectively) or in G2 (p <0.05, p <0.005, p <0.005, respectively). Pulmonary collapse occurred in one lung in G2 and pulmonary artery thrombus in two lungs of G3 and two lungs of G4. The coagulation size of RF ablation of the lung parenchyma is increased by ventilation and particularly by pulmonary artery blood flow restriction. The value of these restrictions for potential clinical use needs to be explored in experimentally induced lung tumors.

KW - Animals

KW - Experimental study

KW - Lung

KW - Radiofrequency (RF) ablation

UR - http://www.scopus.com/inward/record.url?scp=33746412967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746412967&partnerID=8YFLogxK

U2 - 10.1007/s00270-005-0217-7

DO - 10.1007/s00270-005-0217-7

M3 - Article

C2 - 16779691

AN - SCOPUS:33746412967

VL - 29

SP - 838

EP - 845

JO - CardioVascular and Interventional Radiology

JF - CardioVascular and Interventional Radiology

SN - 7415-5101

IS - 5

ER -