Effects of acute oral administration of lithium compounds on multiple schedule performance in rats

D. W. Chrislip, Wyndham Anger, R. J. Smith

Research output: Contribution to journalArticle

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Adult male Sprague-Dawley rats were given acute oral administration of lithium carbonate or lithium chloride at concentrations of 100, 200, and 300 mg/kg. Barpressing performance on a multiple fixed ration 20/fixed interval 5 minute schedule was measured daily. The 200 and 300 mg/kg administrations of lithium chloride produced significant decreases in barpressing performance and all levels of lithium carbonate produced significant changes in performance. A 24 hour delay in the maximal behavioral effect of the 300 mg/kg dose of lithium carbonate paralleled previous findings showing delays in peak brain lithium levels after oral administration of lithium carbonate.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalNeurobehavioral Toxicology and Teratology
Issue number1
Publication statusPublished - 1985
Externally publishedYes


ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Neuropsychology and Physiological Psychology

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