Adult male Sprague-Dawley rats were given acute oral administration of lithium carbonate or lithium chloride at concentrations of 100, 200, and 300 mg/kg. Barpressing performance on a multiple fixed ration 20/fixed interval 5 minute schedule was measured daily. The 200 and 300 mg/kg administrations of lithium chloride produced significant decreases in barpressing performance and all levels of lithium carbonate produced significant changes in performance. A 24 hour delay in the maximal behavioral effect of the 300 mg/kg dose of lithium carbonate paralleled previous findings showing delays in peak brain lithium levels after oral administration of lithium carbonate.
|Original language||English (US)|
|Number of pages||4|
|Journal||Neurobehavioral Toxicology and Teratology|
|State||Published - Jan 1 1985|
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology