Effect of Subthalamic Nucleus Stimulation on Pedunculopontine Nucleus Neural Activity

Ilkay Sitti, Göksemin Acar, Athanasios K. Zisakis, Mevci Özdemir, Feridun Acar, Kim Burchiel

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The pedunculopontine nucleus has recently been proposed as an alternative target for deep brain stimulation for the treatment of medically intractable Parkinson's disease. The suggested indication for pedunculopontine nucleus deep brain stimulation is severe and medically intractable axial symptoms such as gait and postural impairment. Objective: Our goal in this study was to describe the effects of subthalamic nucleus stimulation on pedunculopontine nucleus electrophysiological activity. Methods: Fourteen male Wistar rats were divided into a sham stimulation group and an experimental group. In both groups, electrodes were implanted bilaterally into the subthalamic nucleus and into the right pedunculopontine nucleus. Microelectrode recordings were carried out in both groups prior to and during subthalamic nucleus stimulation. Results: Subthalamic nucleus stimulation produced no clear inhibition of neuronal firing in the pedunculopontine nucleus. However, we found that stimulation of the subthalamic nucleus at 60 Hz produces some entrainment of pedunculopontine nucleus neuronal firing and a shift of subthalamic nucleus firing patterns to more tonic and random patterns. These results are consistent with the effects of deep brain stimulation on neuronal activity in the subthalamic nucleus and globus pallidus internus. Conclusion: The result of this study provides additional evidence to improve our understanding of the mechanism of subthalamic nucleus-deep brain stimulation, and its physiological consequences.

Original languageEnglish (US)
Pages (from-to)54-59
Number of pages6
JournalStereotactic and Functional Neurosurgery
Volume94
Issue number1
DOIs
StatePublished - Apr 1 2016

Fingerprint

Subthalamic Nucleus
Deep Brain Stimulation
Implanted Electrodes
Globus Pallidus
Microelectrodes
Gait
Parkinson Disease
Wistar Rats

Keywords

  • Deep brain stimulation
  • Globus pallidus internus
  • Microelectrode recording
  • Parkinson's disease
  • Pedunculopontine nucleus
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Effect of Subthalamic Nucleus Stimulation on Pedunculopontine Nucleus Neural Activity. / Sitti, Ilkay; Acar, Göksemin; Zisakis, Athanasios K.; Özdemir, Mevci; Acar, Feridun; Burchiel, Kim.

In: Stereotactic and Functional Neurosurgery, Vol. 94, No. 1, 01.04.2016, p. 54-59.

Research output: Contribution to journalArticle

Sitti, Ilkay ; Acar, Göksemin ; Zisakis, Athanasios K. ; Özdemir, Mevci ; Acar, Feridun ; Burchiel, Kim. / Effect of Subthalamic Nucleus Stimulation on Pedunculopontine Nucleus Neural Activity. In: Stereotactic and Functional Neurosurgery. 2016 ; Vol. 94, No. 1. pp. 54-59.
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