Effect of spironolactone on sex hormones in man

B. Stripp, A. A. Taylor, F. C. Bartter, J. R. Gillette, Donald (Lynn) Loriaux, R. Easley, R. H. Menard

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Administration of spironolactone at a dosage of 400 mg/day to healthy male volunteers for 5 days resulted in a significant rise in plasma progesterone and 17α hydroxyprogesterone which persisted throughout the study. A transient increase in plasma FSH and LH concentration was observed after the second but not the third or fifth days of drug administration. There was no change in plasma concentration of testosterone, 17β estradiol, or prolactin. These findings are consistent with a previously reported spironolactone induced destruction of the microsomal enzyme cytochrome P-450, an enzyme necessary for 17 hydroxylase and desmolase activity. The results do not explain the decrease of libido, the impotence, and the gynecomastia frequently associated with spironolactone therapy in males.

Original languageEnglish (US)
Pages (from-to)777-781
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume41
Issue number4
StatePublished - 1975
Externally publishedYes

Fingerprint

Spironolactone
Gonadal Steroid Hormones
Plasmas
17-alpha-Hydroxyprogesterone
Gynecomastia
Libido
Lyases
Erectile Dysfunction
Mixed Function Oxygenases
Prolactin
Cytochrome P-450 Enzyme System
Progesterone
Testosterone
Estradiol
Healthy Volunteers
Enzymes
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Stripp, B., Taylor, A. A., Bartter, F. C., Gillette, J. R., Loriaux, D. L., Easley, R., & Menard, R. H. (1975). Effect of spironolactone on sex hormones in man. Journal of Clinical Endocrinology and Metabolism, 41(4), 777-781.

Effect of spironolactone on sex hormones in man. / Stripp, B.; Taylor, A. A.; Bartter, F. C.; Gillette, J. R.; Loriaux, Donald (Lynn); Easley, R.; Menard, R. H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 41, No. 4, 1975, p. 777-781.

Research output: Contribution to journalArticle

Stripp, B, Taylor, AA, Bartter, FC, Gillette, JR, Loriaux, DL, Easley, R & Menard, RH 1975, 'Effect of spironolactone on sex hormones in man', Journal of Clinical Endocrinology and Metabolism, vol. 41, no. 4, pp. 777-781.
Stripp B, Taylor AA, Bartter FC, Gillette JR, Loriaux DL, Easley R et al. Effect of spironolactone on sex hormones in man. Journal of Clinical Endocrinology and Metabolism. 1975;41(4):777-781.
Stripp, B. ; Taylor, A. A. ; Bartter, F. C. ; Gillette, J. R. ; Loriaux, Donald (Lynn) ; Easley, R. ; Menard, R. H. / Effect of spironolactone on sex hormones in man. In: Journal of Clinical Endocrinology and Metabolism. 1975 ; Vol. 41, No. 4. pp. 777-781.
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