Effect of resistance training on blood oxidative stress in Parkinson disease

Richard J. Bloomer, Brian K. Schilling, Robyn E. Karlage, Mark S. Ledoux, Ronald Pfeiffer, Jonathan Callegari

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Oxidative stress seems to be involved in the pathogenesis of Parkinson disease (PD). Exercise training can increase endogenous antioxidant protection and decrease the production of reactive oxygen and nitrogen species. Purpose: To investigate the effect of exercise training on oxidative status in persons with PD. Methods: Sixteen subjects with PD were match-randomly assigned to resistance exercise (n = 8) or a no-exercise control group (n = 8) on the basis of disease stage (Hoehn and Yahr stages I and II) and sex. Supervised exercise was performed twice weekly for 8 wk, consisting of three sets each of the leg press, leg curl, and calf press. Resting blood samples were taken from subjects before and after the intervention and assayed for markers of oxidative stress [malondialdchydc (MDA) and hydrogen peroxide (H 2O 2)] and antioxidant capacity (superoxide dismutase, catalase, glutathione peroxidase, and trolox-equivalent antioxidant capacity). Results: The exercise program was well-tolerated and associated with modest trends toward decreased oxidative stress and increased antioxidant capacity. The two biomarkers of oxidative stress were decreased after exercise training [MDA (15%) and H 2O 2 (16%)]. With these changes, a postintervention difference was apparent between the resistance exercise training and control groups for H 2O 2 (P = 0.007), with a trend for difference noted for MDA (P = 0.06). The mean increases in superoxide dismutase (9%) and glutathione peroxidase (15%) noted in the exercise training group were not statistically significant (P > 0.05). Conclusions: Short-term resistance training may be associated with reduced oxidative stress in subjects with PD. Future studies with larger samples, inclusive of a higher volume of resistance exercise, are needed to extend these findings.

Original languageEnglish (US)
Pages (from-to)1385-1389
Number of pages5
JournalMedicine and Science in Sports and Exercise
Volume40
Issue number8
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Resistance Training
Parkinson Disease
Oxidative Stress
Exercise
Antioxidants
Glutathione Peroxidase
Superoxide Dismutase
Leg
Reactive Nitrogen Species
Control Groups
Catalase
Hydrogen Peroxide
Reactive Oxygen Species
Biomarkers

Keywords

  • Antioxidant
  • Exercise
  • Free radicals
  • Neurological disease
  • Strength

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of resistance training on blood oxidative stress in Parkinson disease. / Bloomer, Richard J.; Schilling, Brian K.; Karlage, Robyn E.; Ledoux, Mark S.; Pfeiffer, Ronald; Callegari, Jonathan.

In: Medicine and Science in Sports and Exercise, Vol. 40, No. 8, 2008, p. 1385-1389.

Research output: Contribution to journalArticle

Bloomer, Richard J. ; Schilling, Brian K. ; Karlage, Robyn E. ; Ledoux, Mark S. ; Pfeiffer, Ronald ; Callegari, Jonathan. / Effect of resistance training on blood oxidative stress in Parkinson disease. In: Medicine and Science in Sports and Exercise. 2008 ; Vol. 40, No. 8. pp. 1385-1389.
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abstract = "Oxidative stress seems to be involved in the pathogenesis of Parkinson disease (PD). Exercise training can increase endogenous antioxidant protection and decrease the production of reactive oxygen and nitrogen species. Purpose: To investigate the effect of exercise training on oxidative status in persons with PD. Methods: Sixteen subjects with PD were match-randomly assigned to resistance exercise (n = 8) or a no-exercise control group (n = 8) on the basis of disease stage (Hoehn and Yahr stages I and II) and sex. Supervised exercise was performed twice weekly for 8 wk, consisting of three sets each of the leg press, leg curl, and calf press. Resting blood samples were taken from subjects before and after the intervention and assayed for markers of oxidative stress [malondialdchydc (MDA) and hydrogen peroxide (H 2O 2)] and antioxidant capacity (superoxide dismutase, catalase, glutathione peroxidase, and trolox-equivalent antioxidant capacity). Results: The exercise program was well-tolerated and associated with modest trends toward decreased oxidative stress and increased antioxidant capacity. The two biomarkers of oxidative stress were decreased after exercise training [MDA (15{\%}) and H 2O 2 (16{\%})]. With these changes, a postintervention difference was apparent between the resistance exercise training and control groups for H 2O 2 (P = 0.007), with a trend for difference noted for MDA (P = 0.06). The mean increases in superoxide dismutase (9{\%}) and glutathione peroxidase (15{\%}) noted in the exercise training group were not statistically significant (P > 0.05). Conclusions: Short-term resistance training may be associated with reduced oxidative stress in subjects with PD. Future studies with larger samples, inclusive of a higher volume of resistance exercise, are needed to extend these findings.",
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