Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain

Robert Hitzemann, Horace H. Loh, Edward F. Domino

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Para-methoxyamphetamine (PMA) was found to be ineffective in altering the levels of mouse brain DA and NE at doses of 3 and 10 mg/kg but a significant decrease in these amines was observed at 30 mg/kg. In contrast, all doses of PMA tested markedly elevated brain 5-HT and decreased brain 5-HIAA. PMA caused a dose related decrease in the accumulation of 14C-NE formed from 14C-tyrosine but increased the levels of 14C-NE formed from 14C-DOPA. Furthermore, PMA increased the accumulation of 14C-NM formed from 14C-tyrosine in a manner similar to d-amphetamine. Of the doses tested, only 30 mg/kg of PMA increased psychomotor activity.

Original languageEnglish (US)
Pages (from-to)1087-1095
Number of pages9
JournalLife Sciences
Volume10
Issue number19 PART 1
DOIs
StatePublished - Oct 1 1971
Externally publishedYes

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Metabolism
Catecholamines
Brain
Tyrosine
Dextroamphetamine
Hydroxyindoleacetic Acid
Amines
Serotonin
4-methoxyamphetamine

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain. / Hitzemann, Robert; Loh, Horace H.; Domino, Edward F.

In: Life Sciences, Vol. 10, No. 19 PART 1, 01.10.1971, p. 1087-1095.

Research output: Contribution to journalArticle

Hitzemann, Robert ; Loh, Horace H. ; Domino, Edward F. / Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain. In: Life Sciences. 1971 ; Vol. 10, No. 19 PART 1. pp. 1087-1095.
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