Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain

Robert J. Hitzemann, Horace H. Loh, Edward F. Domino

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Para-methoxyamphetamine (PMA) was found to be ineffective in altering the levels of mouse brain DA and NE at doses of 3 and 10 mg/kg but a significant decrease in these amines was observed at 30 mg/kg. In contrast, all doses of PMA tested markedly elevated brain 5-HT and decreased brain 5-HIAA. PMA caused a dose related decrease in the accumulation of 14C-NE formed from 14C-tyrosine but increased the levels of 14C-NE formed from 14C-DOPA. Furthermore, PMA increased the accumulation of 14C-NM formed from 14C-tyrosine in a manner similar to d-amphetamine. Of the doses tested, only 30 mg/kg of PMA increased psychomotor activity.

Original languageEnglish (US)
Pages (from-to)1087-1095
Number of pages9
JournalLife Sciences
Volume10
Issue number19 PART 1
DOIs
StatePublished - Oct 1 1971

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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