Effect of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine

David Lieberman, James Ghormley, Ken Flora

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Oral sodium phosphate is commonly used for colon preparation prior to colonoscopy. Several studies have demonstrated significant changes in serum electrolytes after sodium phosphate preparation, but failed to stratify patients with regard to renal function. The purpose of this study was to determine if electrolyte alterations are observed after sodium phosphate in patients with normal levels of serum creatinine. Methods: Thirty-two patients scheduled for elective colonoscopy who had a serum creatinine level of less than 1.5 mg/dL were enrolled. All patients had a panel of laboratory studies prior to and immediately after receiving oral sodium phosphate colon preparation. Results: Significant increases in serum phosphate and sodium and decreases in serum calcium and potassium were observed. Twenty-eight percent of patients had serum phosphate levels greater than 8.0 mg/dL, and 6% of patients had serum calcium levels less than 8.0 mg/dL after sodium phosphate colon preparation. There were no clinically apparent adverse events. Conclusions: Significant changes in serum electrolyte levels occur after sodium phosphate colon preparation in patients with normal serum creatinine levels. Sodium phosphate could exacerbate pre-existing hypocalcemia or hypokalemia in patients with apparently normal renal function. Therefore, it may be prudent to evaluate serum electrolytes prior to administration of sodium phosphate.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalGastrointestinal Endoscopy
Volume43
Issue number2 PART 2
StatePublished - 1996
Externally publishedYes

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Electrolytes
Creatinine
Colon
Serum
Colonoscopy
sodium phosphate
Calcium
Kidney
Hypokalemia
Hypocalcemia
Potassium
Phosphates

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine. / Lieberman, David; Ghormley, James; Flora, Ken.

In: Gastrointestinal Endoscopy, Vol. 43, No. 2 PART 2, 1996, p. 467-469.

Research output: Contribution to journalArticle

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abstract = "Oral sodium phosphate is commonly used for colon preparation prior to colonoscopy. Several studies have demonstrated significant changes in serum electrolytes after sodium phosphate preparation, but failed to stratify patients with regard to renal function. The purpose of this study was to determine if electrolyte alterations are observed after sodium phosphate in patients with normal levels of serum creatinine. Methods: Thirty-two patients scheduled for elective colonoscopy who had a serum creatinine level of less than 1.5 mg/dL were enrolled. All patients had a panel of laboratory studies prior to and immediately after receiving oral sodium phosphate colon preparation. Results: Significant increases in serum phosphate and sodium and decreases in serum calcium and potassium were observed. Twenty-eight percent of patients had serum phosphate levels greater than 8.0 mg/dL, and 6{\%} of patients had serum calcium levels less than 8.0 mg/dL after sodium phosphate colon preparation. There were no clinically apparent adverse events. Conclusions: Significant changes in serum electrolyte levels occur after sodium phosphate colon preparation in patients with normal serum creatinine levels. Sodium phosphate could exacerbate pre-existing hypocalcemia or hypokalemia in patients with apparently normal renal function. Therefore, it may be prudent to evaluate serum electrolytes prior to administration of sodium phosphate.",
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