Effect of intensive diabetes therapy on diabetic dyslipidemia

Jonathan Purnell, J. D. Brunzell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Alterations in lipoprotein levels and composition may contribute to the greater risk of vascular disease in people with diabetes. The untreated diabetic state is characterized by reduced lipoprotein lipase activity with elevated triglyceride and reduced HDL levels. Lipid levels in IDDM nearly normalize with conventional diabetes therapy and improve with intensive diabetes control, despite significant weight gain. The hypertriglyceridemia and low HDL levels of NIDDM may persist despite institution of diabetes therapy, and the effect of long-term intensive diabetes therapy on lipid levels is not yet known.

Original languageEnglish (US)
Pages (from-to)434-444
Number of pages11
JournalDiabetes Reviews
Volume5
Issue number4
StatePublished - 1997
Externally publishedYes

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Dyslipidemias
Lipids
Lipoprotein Lipase
Hypertriglyceridemia
Type 1 Diabetes Mellitus
Vascular Diseases
Type 2 Diabetes Mellitus
Lipoproteins
Weight Gain
Triglycerides
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Effect of intensive diabetes therapy on diabetic dyslipidemia. / Purnell, Jonathan; Brunzell, J. D.

In: Diabetes Reviews, Vol. 5, No. 4, 1997, p. 434-444.

Research output: Contribution to journalArticle

Purnell, Jonathan ; Brunzell, J. D. / Effect of intensive diabetes therapy on diabetic dyslipidemia. In: Diabetes Reviews. 1997 ; Vol. 5, No. 4. pp. 434-444.
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