Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaques

H. F. Urbanski, J. L. Downs, V. T. Garyfallou, J. A. Mattison, M. A. Lane, G. S. Roth, D. K. Ingram

    Research output: Contribution to journalArticle

    35 Scopus citations

    Abstract

    Although dietary caloric restriction (CR) can retard aging in laboratory rats and mice, it is unclear whether CR can exert similar effects in long-lived species, such as primates. Therefore, we tested the effect of CR on plasma levels of dehydroepiandrosterone sulfate (DHEAS), a reliable endocrine marker of aging. The study included six young (∼10 years) and ten old (∼25 years) male rhesus macaques, approximately half of the animals in each age group having undergone >4 years of 30% CR. Hourly blood samples were collected remotely for 24 hours, through a vascular catheter, and assayed for DHEAS and cortisol. Both of these adrenal steroids showed a pronounced diurnal plasma pattern, with peaks occurring in late morning, but only DHEAS showed an aging-related decline. More importantly, there was no significant difference in plasma DHEAS concentrations between the CR animals and age-matched controls. These data fail to support the hypothesis that CR can attenuate the aging-related decline in plasma DHEAS concentrations, at least not when initiated after puberty.

    Original languageEnglish (US)
    Pages (from-to)443-447
    Number of pages5
    JournalAnnals of the New York Academy of Sciences
    Volume1019
    DOIs
    StatePublished - Jan 1 2004

    Keywords

    • Adrenal gland
    • Dehydroepiandrosterone sulfate
    • Primate

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • History and Philosophy of Science

    Fingerprint Dive into the research topics of 'Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaques'. Together they form a unique fingerprint.

  • Cite this