Effect of butyrate and corticosteroids on retinoblastoma in vitro and in vivo.

M. A. Howard, S. Wardwell, Daniel Albert

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of sodium butyrate (NaB) alone and in combination with a glucocorticoid was studied on Y-79 retinoblastoma cells both in vitro and in vivo. Both NaB (0.5 and 4 mM) and hydrocortisone (1-100 microM) added separately to cells grown in suspension resulted in a small growth inhibition (less than 15%). A marked synergistic effect (75-77% growth inhibition) was observed in vitro when NaB and hydrocortisone were added in combination at all the concentrations tested. With in vivo experiments using the nude mouse model of retinoblastoma, the combination of NaB and methylprednisolone did not inhibit tumor growth.

Original languageEnglish (US)
Pages (from-to)1711-1713
Number of pages3
JournalInvestigative ophthalmology & visual science
Volume32
Issue number6
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Retinoblastoma
Butyrates
Adrenal Cortex Hormones
Hydrocortisone
Growth
Butyric Acid
Methylprednisolone
Nude Mice
Glucocorticoids
Suspensions
In Vitro Techniques
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Effect of butyrate and corticosteroids on retinoblastoma in vitro and in vivo. / Howard, M. A.; Wardwell, S.; Albert, Daniel.

In: Investigative ophthalmology & visual science, Vol. 32, No. 6, 01.01.1991, p. 1711-1713.

Research output: Contribution to journalArticle

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