Abstract
Recent studies suggest that the pressor response to exogenous angiotensin II infusion may, through baroreceptor-dependent mechanisms, counteract the stimulatory effect of the peptide on vasopressin and adrenocorticotropic hormone (ACTH) secretion. To test this hypothesis, the effect of combined cardiac and sinoaortic baroreceptor denervation on the increases in plasma concentrations of vasopressin and cortisol (used as an index of ACTH secretion) produced by angiotensin II infusion was studied in conscious dogs. In eight intact dogs, 30-min angiotensin II infusions at 5, 10, and 20 ng · kg-1 · min-1 increased mean arterial pressure from 108 ± 5 to 126 ± 5 mmHg, from 101 ± 4 to 130 ± 4 mmHg, and from 99 ± 3 to 138 ± 4 mmHg, respectively (P <0.001). Plasma cortisol concentration increased from 19 ± 4 to 27 ± 4 ng/ml, from 19 ± 4 to 43 ± 4 ng/ml, and from 19 ± 4 to 71 ± 6 ng/ml (P <0.01), and plasma vasopressin concentration increased from 2.2 ± 0.3 to 3.1 ± 0.3 pg/ml, from 2.3 ± 0.3 to 3.5 ± 0.4 pg/ml, and from 2.2 ± 0.4 to 5.0 ± 0.5 pg/ml (P <0.01). In five to six baroreceptor-denervated dogs, angiotensin II infusion produced increases in mean arterial pressure, plasma vasopressin concentration, and plasma cortisol concentration that were not consistently different from those in the intact dogs. These results demonstrate that baroreceptor denervation does not enhance the vasopressin or cortisol responses to angiotensin II infusion in conscious dogs.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 257 |
| Issue number | 5 |
| State | Published - 1989 |
| Externally published | Yes |
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Keywords
- adrenocorticotropic hormone
- baroreceptor reflex
- baroreceptors
- blood pressure
- cardiac denervation
- heart rate
- nitroprusside
ASJC Scopus subject areas
- Physiology
Cite this
Effect of baroreceptor denervation on vasopressin and cortisol responses to angiotensin II infusion in conscious dogs. / Brooks, Virginia; Klingbeil, C. K.; Quillen, E. W.; Keil, L. C.; Reid, I. A.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 257, No. 5, 1989.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of baroreceptor denervation on vasopressin and cortisol responses to angiotensin II infusion in conscious dogs
AU - Brooks, Virginia
AU - Klingbeil, C. K.
AU - Quillen, E. W.
AU - Keil, L. C.
AU - Reid, I. A.
PY - 1989
Y1 - 1989
N2 - Recent studies suggest that the pressor response to exogenous angiotensin II infusion may, through baroreceptor-dependent mechanisms, counteract the stimulatory effect of the peptide on vasopressin and adrenocorticotropic hormone (ACTH) secretion. To test this hypothesis, the effect of combined cardiac and sinoaortic baroreceptor denervation on the increases in plasma concentrations of vasopressin and cortisol (used as an index of ACTH secretion) produced by angiotensin II infusion was studied in conscious dogs. In eight intact dogs, 30-min angiotensin II infusions at 5, 10, and 20 ng · kg-1 · min-1 increased mean arterial pressure from 108 ± 5 to 126 ± 5 mmHg, from 101 ± 4 to 130 ± 4 mmHg, and from 99 ± 3 to 138 ± 4 mmHg, respectively (P <0.001). Plasma cortisol concentration increased from 19 ± 4 to 27 ± 4 ng/ml, from 19 ± 4 to 43 ± 4 ng/ml, and from 19 ± 4 to 71 ± 6 ng/ml (P <0.01), and plasma vasopressin concentration increased from 2.2 ± 0.3 to 3.1 ± 0.3 pg/ml, from 2.3 ± 0.3 to 3.5 ± 0.4 pg/ml, and from 2.2 ± 0.4 to 5.0 ± 0.5 pg/ml (P <0.01). In five to six baroreceptor-denervated dogs, angiotensin II infusion produced increases in mean arterial pressure, plasma vasopressin concentration, and plasma cortisol concentration that were not consistently different from those in the intact dogs. These results demonstrate that baroreceptor denervation does not enhance the vasopressin or cortisol responses to angiotensin II infusion in conscious dogs.
AB - Recent studies suggest that the pressor response to exogenous angiotensin II infusion may, through baroreceptor-dependent mechanisms, counteract the stimulatory effect of the peptide on vasopressin and adrenocorticotropic hormone (ACTH) secretion. To test this hypothesis, the effect of combined cardiac and sinoaortic baroreceptor denervation on the increases in plasma concentrations of vasopressin and cortisol (used as an index of ACTH secretion) produced by angiotensin II infusion was studied in conscious dogs. In eight intact dogs, 30-min angiotensin II infusions at 5, 10, and 20 ng · kg-1 · min-1 increased mean arterial pressure from 108 ± 5 to 126 ± 5 mmHg, from 101 ± 4 to 130 ± 4 mmHg, and from 99 ± 3 to 138 ± 4 mmHg, respectively (P <0.001). Plasma cortisol concentration increased from 19 ± 4 to 27 ± 4 ng/ml, from 19 ± 4 to 43 ± 4 ng/ml, and from 19 ± 4 to 71 ± 6 ng/ml (P <0.01), and plasma vasopressin concentration increased from 2.2 ± 0.3 to 3.1 ± 0.3 pg/ml, from 2.3 ± 0.3 to 3.5 ± 0.4 pg/ml, and from 2.2 ± 0.4 to 5.0 ± 0.5 pg/ml (P <0.01). In five to six baroreceptor-denervated dogs, angiotensin II infusion produced increases in mean arterial pressure, plasma vasopressin concentration, and plasma cortisol concentration that were not consistently different from those in the intact dogs. These results demonstrate that baroreceptor denervation does not enhance the vasopressin or cortisol responses to angiotensin II infusion in conscious dogs.
KW - adrenocorticotropic hormone
KW - baroreceptor reflex
KW - baroreceptors
KW - blood pressure
KW - cardiac denervation
KW - heart rate
KW - nitroprusside
UR - http://www.scopus.com/inward/record.url?scp=0024326925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024326925&partnerID=8YFLogxK
M3 - Article
C2 - 2589543
AN - SCOPUS:0024326925
VL - 257
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 5
ER -