Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci

Richard Bryant, J. A. Mazza, E. M. Gardner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The antistaphylococcal activity of LY146032 was tested in human pus in vitro and in a murine abscess model in vivo. The drug was not degraded by pus containingΒlactamase and had equally good or better activity than nafcillin or vancomycin againstStaphylococcus aureus or Staphylococcus epidermidisin vitro and in vivo. Its activity was slightly enhanced when used in combination with rifampin and tobramycin.

Original languageEnglish (US)
Pages (from-to)186-188
Number of pages3
JournalEuropean Journal of Clinical Microbiology
Volume6
Issue number2
DOIs
StatePublished - Apr 1987

Fingerprint

Daptomycin
Suppuration
Staphylococcus
Abscess
Nafcillin
Tobramycin
Vancomycin
Rifampin
Staphylococcus aureus
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci. / Bryant, Richard; Mazza, J. A.; Gardner, E. M.

In: European Journal of Clinical Microbiology, Vol. 6, No. 2, 04.1987, p. 186-188.

Research output: Contribution to journalArticle

Bryant, Richard ; Mazza, J. A. ; Gardner, E. M. / Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci. In: European Journal of Clinical Microbiology. 1987 ; Vol. 6, No. 2. pp. 186-188.
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