Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne

John J. Digiovanna, Craig B. Langman, Eduardo H. Tschen, Terry Jones, Alan Menter, Nicholas J. Lowe, Lawrence Eichenfield, Adelaide A. Hebert, David Pariser, Ronald P. Savin, Stacy R. Smith, Michael Jarratt, David Rodriguez, Dan K. Chalker, Steven Kempers, Mark Ling, Elyse S. Rafal, Sabra Sullivan, Sewon Kang, Leena P. ShahEmily Wu, Julie Newhouse, Jonathan Pak, Douglas R. Eberhardt, Graeme F. Bryce, John A. McLane, Michael Ondovik, Catherine Chin, Ko Chin Khoo, Phoebe Rich

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background Adverse changes in bone have been reported for patients undergoing high-dose, long-term (several years) isotretinoin therapy for disorders of cornification. The effect of short-term (4-5 months) therapy at the lower dose recommended for acne on bone development in younger, growing adolescent (12-17 years) patients has not been well studied. Objective The purpose of the study was to evaluate the effect of a standard, single course of isotretinoin (Accutane) therapy on bone mineral density (BMD) of the lumbar spine and hip in adolescents ages 12 to 17 years with severe, recalcitrant, nodular acne. Methods In this open-label, multicenter study, 217 adolescents (81 girls) with severe, recalcitrant, nodular acne were enrolled and treated with isotretinoin twice daily with food at the recommended total dose of approximately 1 mg/kg for 16 to 20 weeks. BMD in the lumbar spine and hip was measured at baseline and at the end of therapy by dual energy radiograph absorptiometry. Results There was no clinically significant mean change in BMD measured at the lumbar spine (+1.4%, range: -4.9% to +12.3%) or total hip (-0.26%, range: -11.3% to +15.0%). Hyperostosis was not observed in any patient. Typical effixcacy expected in the treatment of acne was observed. Conclusions A 16- to 20-week course of isotretinoin treatment at the recommended dose for severe acne has no clinically significant effect on lumbar spine and total hip BMD in the adolescent (12-17 years) population.

Original languageEnglish (US)
Pages (from-to)709-717
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume51
Issue number5
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

Fingerprint

Isotretinoin
Acne Vulgaris
Bone Density
Spine
Hip
Therapeutics
Pelvic Bones
Hyperostosis
Bone Development
Multicenter Studies
Bone and Bones
Food
Population

ASJC Scopus subject areas

  • Dermatology

Cite this

Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne. / Digiovanna, John J.; Langman, Craig B.; Tschen, Eduardo H.; Jones, Terry; Menter, Alan; Lowe, Nicholas J.; Eichenfield, Lawrence; Hebert, Adelaide A.; Pariser, David; Savin, Ronald P.; Smith, Stacy R.; Jarratt, Michael; Rodriguez, David; Chalker, Dan K.; Kempers, Steven; Ling, Mark; Rafal, Elyse S.; Sullivan, Sabra; Kang, Sewon; Shah, Leena P.; Wu, Emily; Newhouse, Julie; Pak, Jonathan; Eberhardt, Douglas R.; Bryce, Graeme F.; McLane, John A.; Ondovik, Michael; Chin, Catherine; Khoo, Ko Chin; Rich, Phoebe.

In: Journal of the American Academy of Dermatology, Vol. 51, No. 5, 01.11.2004, p. 709-717.

Research output: Contribution to journalArticle

Digiovanna, JJ, Langman, CB, Tschen, EH, Jones, T, Menter, A, Lowe, NJ, Eichenfield, L, Hebert, AA, Pariser, D, Savin, RP, Smith, SR, Jarratt, M, Rodriguez, D, Chalker, DK, Kempers, S, Ling, M, Rafal, ES, Sullivan, S, Kang, S, Shah, LP, Wu, E, Newhouse, J, Pak, J, Eberhardt, DR, Bryce, GF, McLane, JA, Ondovik, M, Chin, C, Khoo, KC & Rich, P 2004, 'Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne', Journal of the American Academy of Dermatology, vol. 51, no. 5, pp. 709-717. https://doi.org/10.1016/j.jaad.2004.04.032
Digiovanna, John J. ; Langman, Craig B. ; Tschen, Eduardo H. ; Jones, Terry ; Menter, Alan ; Lowe, Nicholas J. ; Eichenfield, Lawrence ; Hebert, Adelaide A. ; Pariser, David ; Savin, Ronald P. ; Smith, Stacy R. ; Jarratt, Michael ; Rodriguez, David ; Chalker, Dan K. ; Kempers, Steven ; Ling, Mark ; Rafal, Elyse S. ; Sullivan, Sabra ; Kang, Sewon ; Shah, Leena P. ; Wu, Emily ; Newhouse, Julie ; Pak, Jonathan ; Eberhardt, Douglas R. ; Bryce, Graeme F. ; McLane, John A. ; Ondovik, Michael ; Chin, Catherine ; Khoo, Ko Chin ; Rich, Phoebe. / Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne. In: Journal of the American Academy of Dermatology. 2004 ; Vol. 51, No. 5. pp. 709-717.
@article{4d4852a816244a01b477412bd6c65cbd,
title = "Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne",
abstract = "Background Adverse changes in bone have been reported for patients undergoing high-dose, long-term (several years) isotretinoin therapy for disorders of cornification. The effect of short-term (4-5 months) therapy at the lower dose recommended for acne on bone development in younger, growing adolescent (12-17 years) patients has not been well studied. Objective The purpose of the study was to evaluate the effect of a standard, single course of isotretinoin (Accutane) therapy on bone mineral density (BMD) of the lumbar spine and hip in adolescents ages 12 to 17 years with severe, recalcitrant, nodular acne. Methods In this open-label, multicenter study, 217 adolescents (81 girls) with severe, recalcitrant, nodular acne were enrolled and treated with isotretinoin twice daily with food at the recommended total dose of approximately 1 mg/kg for 16 to 20 weeks. BMD in the lumbar spine and hip was measured at baseline and at the end of therapy by dual energy radiograph absorptiometry. Results There was no clinically significant mean change in BMD measured at the lumbar spine (+1.4{\%}, range: -4.9{\%} to +12.3{\%}) or total hip (-0.26{\%}, range: -11.3{\%} to +15.0{\%}). Hyperostosis was not observed in any patient. Typical effixcacy expected in the treatment of acne was observed. Conclusions A 16- to 20-week course of isotretinoin treatment at the recommended dose for severe acne has no clinically significant effect on lumbar spine and total hip BMD in the adolescent (12-17 years) population.",
author = "Digiovanna, {John J.} and Langman, {Craig B.} and Tschen, {Eduardo H.} and Terry Jones and Alan Menter and Lowe, {Nicholas J.} and Lawrence Eichenfield and Hebert, {Adelaide A.} and David Pariser and Savin, {Ronald P.} and Smith, {Stacy R.} and Michael Jarratt and David Rodriguez and Chalker, {Dan K.} and Steven Kempers and Mark Ling and Rafal, {Elyse S.} and Sabra Sullivan and Sewon Kang and Shah, {Leena P.} and Emily Wu and Julie Newhouse and Jonathan Pak and Eberhardt, {Douglas R.} and Bryce, {Graeme F.} and McLane, {John A.} and Michael Ondovik and Catherine Chin and Khoo, {Ko Chin} and Phoebe Rich",
year = "2004",
month = "11",
day = "1",
doi = "10.1016/j.jaad.2004.04.032",
language = "English (US)",
volume = "51",
pages = "709--717",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne

AU - Digiovanna, John J.

AU - Langman, Craig B.

AU - Tschen, Eduardo H.

AU - Jones, Terry

AU - Menter, Alan

AU - Lowe, Nicholas J.

AU - Eichenfield, Lawrence

AU - Hebert, Adelaide A.

AU - Pariser, David

AU - Savin, Ronald P.

AU - Smith, Stacy R.

AU - Jarratt, Michael

AU - Rodriguez, David

AU - Chalker, Dan K.

AU - Kempers, Steven

AU - Ling, Mark

AU - Rafal, Elyse S.

AU - Sullivan, Sabra

AU - Kang, Sewon

AU - Shah, Leena P.

AU - Wu, Emily

AU - Newhouse, Julie

AU - Pak, Jonathan

AU - Eberhardt, Douglas R.

AU - Bryce, Graeme F.

AU - McLane, John A.

AU - Ondovik, Michael

AU - Chin, Catherine

AU - Khoo, Ko Chin

AU - Rich, Phoebe

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Background Adverse changes in bone have been reported for patients undergoing high-dose, long-term (several years) isotretinoin therapy for disorders of cornification. The effect of short-term (4-5 months) therapy at the lower dose recommended for acne on bone development in younger, growing adolescent (12-17 years) patients has not been well studied. Objective The purpose of the study was to evaluate the effect of a standard, single course of isotretinoin (Accutane) therapy on bone mineral density (BMD) of the lumbar spine and hip in adolescents ages 12 to 17 years with severe, recalcitrant, nodular acne. Methods In this open-label, multicenter study, 217 adolescents (81 girls) with severe, recalcitrant, nodular acne were enrolled and treated with isotretinoin twice daily with food at the recommended total dose of approximately 1 mg/kg for 16 to 20 weeks. BMD in the lumbar spine and hip was measured at baseline and at the end of therapy by dual energy radiograph absorptiometry. Results There was no clinically significant mean change in BMD measured at the lumbar spine (+1.4%, range: -4.9% to +12.3%) or total hip (-0.26%, range: -11.3% to +15.0%). Hyperostosis was not observed in any patient. Typical effixcacy expected in the treatment of acne was observed. Conclusions A 16- to 20-week course of isotretinoin treatment at the recommended dose for severe acne has no clinically significant effect on lumbar spine and total hip BMD in the adolescent (12-17 years) population.

AB - Background Adverse changes in bone have been reported for patients undergoing high-dose, long-term (several years) isotretinoin therapy for disorders of cornification. The effect of short-term (4-5 months) therapy at the lower dose recommended for acne on bone development in younger, growing adolescent (12-17 years) patients has not been well studied. Objective The purpose of the study was to evaluate the effect of a standard, single course of isotretinoin (Accutane) therapy on bone mineral density (BMD) of the lumbar spine and hip in adolescents ages 12 to 17 years with severe, recalcitrant, nodular acne. Methods In this open-label, multicenter study, 217 adolescents (81 girls) with severe, recalcitrant, nodular acne were enrolled and treated with isotretinoin twice daily with food at the recommended total dose of approximately 1 mg/kg for 16 to 20 weeks. BMD in the lumbar spine and hip was measured at baseline and at the end of therapy by dual energy radiograph absorptiometry. Results There was no clinically significant mean change in BMD measured at the lumbar spine (+1.4%, range: -4.9% to +12.3%) or total hip (-0.26%, range: -11.3% to +15.0%). Hyperostosis was not observed in any patient. Typical effixcacy expected in the treatment of acne was observed. Conclusions A 16- to 20-week course of isotretinoin treatment at the recommended dose for severe acne has no clinically significant effect on lumbar spine and total hip BMD in the adolescent (12-17 years) population.

UR - http://www.scopus.com/inward/record.url?scp=8744232244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8744232244&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2004.04.032

DO - 10.1016/j.jaad.2004.04.032

M3 - Article

C2 - 15523348

AN - SCOPUS:8744232244

VL - 51

SP - 709

EP - 717

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 5

ER -