Eculizumab for the treatment of preeclampsia/HELLP syndrome

R. M. Burwick, B. B. Feinberg

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

Severe preeclampsia with hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome is a leading cause of maternal and neonatal morbidity and mortality worldwide. Occurrence at an extremely premature gestational age is most challenging as there are dichotomous imperatives: delivery as definitive therapy for maternal health vs. prolongation of pregnancy to avoid prematurity and associated morbidities. We describe a patient presenting with severe preeclampsia/HELLP syndrome at 26 weeks gestation that was treated with Eculizumab, a targeted inhibitor of complement protein C5, which resulted in marked clinical improvement and complete normalization of lab parameters. Pregnancy was prolonged 17 days, likely resulting in a reduction of neonatal morbidity with its associated short and long-term health care costs. Successful use of Eculizumab in this case suggests that complement inhibition may be an effective treatment strategy for severe preeclampsia/HELLP syndrome.

Original languageEnglish (US)
Pages (from-to)201-203
Number of pages3
JournalPlacenta
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • C5
  • Complement
  • Eculizumab
  • HELLP syndrome
  • Preeclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Eculizumab for the treatment of preeclampsia/HELLP syndrome'. Together they form a unique fingerprint.

  • Cite this