TY - JOUR
T1 - Economic Evaluation of Dupilumab for the Treatment of Moderate-to-Severe Atopic Dermatitis in Adults
AU - Kuznik, Andreas
AU - Bégo-Le-Bagousse, Gaëlle
AU - Eckert, Laurent
AU - Gadkari, Abhijit
AU - Simpson, Eric
AU - Graham, Christopher N.
AU - Miles, La Stella
AU - Mastey, Vera
AU - Mahajan, Puneet
AU - Sullivan, Sean D.
N1 - Funding Information:
Disclosures. This study was conducted by RTI Health Solutions under the direction of Sanofi and Regeneron Pharmaceuticals, Inc. Andreas Kuznik is an employee of Regeneron Pharmaceuticals, Inc. Abhijit Gadkari is an employee of Regeneron Pharmaceuticals, Inc. Vera Mastey is an employee of Regeneron Pharmaceuticals, Inc. Gaëlle Bégo-Le-Bagousse is an employee of Sanofi. Laurent Eckert is an employee of Sanofi. Puneet Mahajan is an employee of Sanofi. Christopher N. Graham is an employee of RTI Health Solutions, which was funded in connection with development and implementation of the economic model. LaS-tella Miles is an employee of RTI Health Solutions, which was funded in connection with development and implementation of the economic model. Eric Simpson received no honoraria related to the development of this publication. Sean Sullivan received no honoraria related to the development of this publication. Eric Simpson’s institution has received grants/research funding from Amgen, Inc., Anacor Pharmaceuticals Inc., Celgene Corporation, Chugai Pharma USA, LLC, Eli Lilly and Company, Galderma Research and Development, Genentech Inc., MedImmune LLC, Novartis Pharmaceuticals Corporation, Pfizer Inc., Regeneron Pharmaceuticals, Inc., Sanofi, and Tioga Pharmaceuticals Inc., and he is a consultant for Regeneron Pharmaceuticals, Inc., Sanofi, Anacor, Celgene Corporation, Galderma Research and Development, Genentech, MedImmune LLC, Pfizer Inc., Abbvie, Dermira, and Valeant.
Funding Information:
The study and article processing charges were funded by Sanofi and Regeneron Pharmaceuticals, Inc. All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis. Medical writing support was provided by E. Jay Bienen, funded by Sanofi and Regeneron Pharmaceuticals, Inc. The authors are responsible for all content and editorial decisions. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.
Publisher Copyright:
© 2017, The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Introduction: Dupilumab significantly improves signs and symptoms of atopic dermatitis (AD), including pruritus, symptoms of anxiety and depression, and health-related quality of life versus placebo in adults with moderate-to-severe AD. Since the cost-effectiveness of dupilumab has not been evaluated, the objective of this analysis was to estimate a value-based price range in which dupilumab would be considered cost-effective compared with supportive care (SC) for treatment of moderate-to-severe AD in an adult population. Methods: A health economic model was developed to evaluate from the US payer perspective the long-term costs and benefits of dupilumab treatment administered every other week (q2w). Dupilumab q2w was compared with SC; robustness of assumptions and results were tested using sensitivity and scenario analyses. Clinical data were derived from the dupilumab LIBERTY AD SOLO trials; healthcare use and cost data were from health insurance claims histories of adult patients with AD. The annual price of maintenance therapy with dupilumab to be considered cost-effective was estimated for decision thresholds of US100,000 and 150,000 per quality-adjusted life-year (QALY) gained. Results: In the base case, the annual maintenance price for dupilumab therapy to be considered cost-effective would be 28,770 at a 100,000 per QALY gained threshold, and 39,940 at a 150,000 threshold. Results were generally robust to parameter variations in one-way and probabilistic sensitivity analyses. Conclusion: Dupilumab q2w compared with SC is cost-effective for the treatment of moderate-to-severe AD in US adults at an annual price of maintenance therapy in the range of 29,000–40,000 at the 100,000–150,000 per QALY thresholds. Funding: Sanofi and Regeneron Pharmaceuticals, Inc.
AB - Introduction: Dupilumab significantly improves signs and symptoms of atopic dermatitis (AD), including pruritus, symptoms of anxiety and depression, and health-related quality of life versus placebo in adults with moderate-to-severe AD. Since the cost-effectiveness of dupilumab has not been evaluated, the objective of this analysis was to estimate a value-based price range in which dupilumab would be considered cost-effective compared with supportive care (SC) for treatment of moderate-to-severe AD in an adult population. Methods: A health economic model was developed to evaluate from the US payer perspective the long-term costs and benefits of dupilumab treatment administered every other week (q2w). Dupilumab q2w was compared with SC; robustness of assumptions and results were tested using sensitivity and scenario analyses. Clinical data were derived from the dupilumab LIBERTY AD SOLO trials; healthcare use and cost data were from health insurance claims histories of adult patients with AD. The annual price of maintenance therapy with dupilumab to be considered cost-effective was estimated for decision thresholds of US100,000 and 150,000 per quality-adjusted life-year (QALY) gained. Results: In the base case, the annual maintenance price for dupilumab therapy to be considered cost-effective would be 28,770 at a 100,000 per QALY gained threshold, and 39,940 at a 150,000 threshold. Results were generally robust to parameter variations in one-way and probabilistic sensitivity analyses. Conclusion: Dupilumab q2w compared with SC is cost-effective for the treatment of moderate-to-severe AD in US adults at an annual price of maintenance therapy in the range of 29,000–40,000 at the 100,000–150,000 per QALY thresholds. Funding: Sanofi and Regeneron Pharmaceuticals, Inc.
KW - Atopic dermatitis
KW - Cost-effectiveness
KW - Dupilumab
KW - Eczema
KW - Health economics
KW - Quality-adjusted life-years
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U2 - 10.1007/s13555-017-0201-6
DO - 10.1007/s13555-017-0201-6
M3 - Article
AN - SCOPUS:85035209828
VL - 7
SP - 493
EP - 505
JO - Dermatology and Therapy
JF - Dermatology and Therapy
SN - 2190-9172
IS - 4
ER -