Economic Evaluation of Dupilumab for the Treatment of Moderate-to-Severe Atopic Dermatitis in Adults

Andreas Kuznik, Gaëlle Bégo-Le-Bagousse, Laurent Eckert, Abhijit Gadkari, Eric Simpson, Christopher N. Graham, La Stella Miles, Vera Mastey, Puneet Mahajan, Sean D. Sullivan

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Introduction: Dupilumab significantly improves signs and symptoms of atopic dermatitis (AD), including pruritus, symptoms of anxiety and depression, and health-related quality of life versus placebo in adults with moderate-to-severe AD. Since the cost-effectiveness of dupilumab has not been evaluated, the objective of this analysis was to estimate a value-based price range in which dupilumab would be considered cost-effective compared with supportive care (SC) for treatment of moderate-to-severe AD in an adult population. Methods: A health economic model was developed to evaluate from the US payer perspective the long-term costs and benefits of dupilumab treatment administered every other week (q2w). Dupilumab q2w was compared with SC; robustness of assumptions and results were tested using sensitivity and scenario analyses. Clinical data were derived from the dupilumab LIBERTY AD SOLO trials; healthcare use and cost data were from health insurance claims histories of adult patients with AD. The annual price of maintenance therapy with dupilumab to be considered cost-effective was estimated for decision thresholds of US100,000 and 150,000 per quality-adjusted life-year (QALY) gained. Results: In the base case, the annual maintenance price for dupilumab therapy to be considered cost-effective would be 28,770 at a 100,000 per QALY gained threshold, and 39,940 at a 150,000 threshold. Results were generally robust to parameter variations in one-way and probabilistic sensitivity analyses. Conclusion: Dupilumab q2w compared with SC is cost-effective for the treatment of moderate-to-severe AD in US adults at an annual price of maintenance therapy in the range of 29,000–40,000 at the 100,000–150,000 per QALY thresholds. Funding: Sanofi and Regeneron Pharmaceuticals, Inc.

Original languageEnglish (US)
Pages (from-to)493-505
Number of pages13
JournalDermatology and Therapy
Volume7
Issue number4
DOIs
StatePublished - Dec 1 2017

Keywords

  • Atopic dermatitis
  • Cost-effectiveness
  • Dupilumab
  • Eczema
  • Health economics
  • Quality-adjusted life-years

ASJC Scopus subject areas

  • Dermatology

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    Kuznik, A., Bégo-Le-Bagousse, G., Eckert, L., Gadkari, A., Simpson, E., Graham, C. N., Miles, L. S., Mastey, V., Mahajan, P., & Sullivan, S. D. (2017). Economic Evaluation of Dupilumab for the Treatment of Moderate-to-Severe Atopic Dermatitis in Adults. Dermatology and Therapy, 7(4), 493-505. https://doi.org/10.1007/s13555-017-0201-6