Early Post-transplant Lymphoproliferative Disease in the Donor Ureter Without Systemic Involvement: A Case Report

W. M. Bennett; T. D. Batiuk; K. M. McEvoy; V. Douzdjian; J. Hyde; C. Shaut; G. M. Segal

doi:10.1016/j.transproceed.2015.07.005

Early Post-transplant Lymphoproliferative Disease in the Donor Ureter Without Systemic Involvement: A Case Report

W. M. Bennett, T. D. Batiuk, K. M. McEvoy, V. Douzdjian, J. Hyde, C. Shaut, G. M. Segal

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background Post-transplant lymphoproliferative disease is a serious complication of renal transplantation. Major risk factors include Epstein-Barr virus (EBV) seronegativity and induction immunosuppression with lymphocyte-depleting agents. Results We present a case of a 50-year year-old woman with very early onset PTLD confined to the donor ureter. Phenotypic studies on the tumor material reveal that the lymphoma was most likely of donor origin. A complete staging workup including the kidney allograft was negative for any other sites of involvement. Conclusions This case, which had a fatal outcome, emphasizes the risk of renal transplantation in BV-negative individuals when given induction with lymphocyte-depleting drugs.

Original language	English (US)
Pages (from-to)	2301-2303
Number of pages	3
Journal	Transplantation proceedings
Volume	47
Issue number	7
DOIs	https://doi.org/10.1016/j.transproceed.2015.07.005
State	Published - Sep 1 2015

ASJC Scopus subject areas

Surgery
Transplantation

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10.1016/j.transproceed.2015.07.005

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title = "Early Post-transplant Lymphoproliferative Disease in the Donor Ureter Without Systemic Involvement: A Case Report",

abstract = "Background Post-transplant lymphoproliferative disease is a serious complication of renal transplantation. Major risk factors include Epstein-Barr virus (EBV) seronegativity and induction immunosuppression with lymphocyte-depleting agents. Results We present a case of a 50-year year-old woman with very early onset PTLD confined to the donor ureter. Phenotypic studies on the tumor material reveal that the lymphoma was most likely of donor origin. A complete staging workup including the kidney allograft was negative for any other sites of involvement. Conclusions This case, which had a fatal outcome, emphasizes the risk of renal transplantation in BV-negative individuals when given induction with lymphocyte-depleting drugs.",

author = "Bennett, {W. M.} and Batiuk, {T. D.} and McEvoy, {K. M.} and V. Douzdjian and J. Hyde and C. Shaut and Segal, {G. M.}",

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T1 - Early Post-transplant Lymphoproliferative Disease in the Donor Ureter Without Systemic Involvement

T2 - A Case Report

AU - Bennett, W. M.

AU - Batiuk, T. D.

AU - McEvoy, K. M.

AU - Douzdjian, V.

AU - Hyde, J.

AU - Shaut, C.

AU - Segal, G. M.

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Y1 - 2015/9/1

N2 - Background Post-transplant lymphoproliferative disease is a serious complication of renal transplantation. Major risk factors include Epstein-Barr virus (EBV) seronegativity and induction immunosuppression with lymphocyte-depleting agents. Results We present a case of a 50-year year-old woman with very early onset PTLD confined to the donor ureter. Phenotypic studies on the tumor material reveal that the lymphoma was most likely of donor origin. A complete staging workup including the kidney allograft was negative for any other sites of involvement. Conclusions This case, which had a fatal outcome, emphasizes the risk of renal transplantation in BV-negative individuals when given induction with lymphocyte-depleting drugs.

AB - Background Post-transplant lymphoproliferative disease is a serious complication of renal transplantation. Major risk factors include Epstein-Barr virus (EBV) seronegativity and induction immunosuppression with lymphocyte-depleting agents. Results We present a case of a 50-year year-old woman with very early onset PTLD confined to the donor ureter. Phenotypic studies on the tumor material reveal that the lymphoma was most likely of donor origin. A complete staging workup including the kidney allograft was negative for any other sites of involvement. Conclusions This case, which had a fatal outcome, emphasizes the risk of renal transplantation in BV-negative individuals when given induction with lymphocyte-depleting drugs.

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Early Post-transplant Lymphoproliferative Disease in the Donor Ureter Without Systemic Involvement: A Case Report

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