Early-Onset Pauciarticular Juvenile Rheumatoid Arthritis

A Histopathologic Study

John C. Merriam, Leo T. Chylack, Daniel Albert

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A young girl with early-onset pauciarticular juvenile rheumatoid arthritis suffered from recurrent severe bilateral iridocyclitis. Despite intensive medical therapy, she gradually lost all useful vision and ultimately required bilateral enucleation at the age of 10 years for control of pain and photophobia. Histopathologic study of the eyes revealed in the iris and ciliary body a dense inflammatory infiltrate composed principally of plasma cells, as well as angle closure, a dense cyclitic membrane, retinal detachment, cystoid macula, and optic atrophy. Immunoperoxidase stains showed little immunoglobulin within or around the plasma cells within the ciliary body, although strong reactions for IgG and κ- and λ-light chains were seen in other parts of the eyes.

Original languageEnglish (US)
Pages (from-to)1085-1092
Number of pages8
JournalArchives of Ophthalmology
Volume101
Issue number7
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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Ciliary Body
Juvenile Arthritis
Plasma Cells
Iridocyclitis
Optic Atrophy
Photophobia
Iris
Retinal Detachment
Immunoglobulins
Coloring Agents
Immunoglobulin G
Light
Pain
Membranes
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Early-Onset Pauciarticular Juvenile Rheumatoid Arthritis : A Histopathologic Study. / Merriam, John C.; Chylack, Leo T.; Albert, Daniel.

In: Archives of Ophthalmology, Vol. 101, No. 7, 01.01.1983, p. 1085-1092.

Research output: Contribution to journalArticle

Merriam, John C. ; Chylack, Leo T. ; Albert, Daniel. / Early-Onset Pauciarticular Juvenile Rheumatoid Arthritis : A Histopathologic Study. In: Archives of Ophthalmology. 1983 ; Vol. 101, No. 7. pp. 1085-1092.
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