Dystroglycan

Emerging roles in mammary gland function

M. Lynn Weir, John Muschler

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Dystroglycan (DG) is a single receptor that binds to multiple basement membrane proteins and forms a transmembrane link to the actin cytoskeleton. It was first isolated as a component of the dystrophin-glycoprotein complex, which plays a role in the maintenance of muscle cell integrity and is defective in many muscular dystrophies. Although studied most extensively in muscle tissues, DG is present at most cell-basement membrane interfaces, and only recently has investigation of DG functions in nonmuscle cells gained momentum. Information emerging from recent studies in epithelial cells is implicating DG in a wide range of critical cell responses to the basement membrane, ranging from organization of tissue architecture to cell survival. Moreover, DG functions appear to be frequently absent in carcinoma cells, implicating its loss in cancer progression. Although many questions remain as to its precise role in mammary tissue, DG is emerging as a potentially important player in mammary gland function.

Original languageEnglish (US)
Pages (from-to)409-419
Number of pages11
JournalJournal of Mammary Gland Biology and Neoplasia
Volume8
Issue number4
DOIs
StatePublished - Oct 2003
Externally publishedYes

Fingerprint

Dystroglycans
Human Mammary Glands
Basement Membrane
Dystrophin
Muscular Dystrophies
Actin Cytoskeleton
Muscle Cells
Cell Survival
Glycoproteins
Membrane Proteins
Breast
Epithelial Cells
Maintenance
Cell Membrane
Carcinoma
Muscles

Keywords

  • Breast
  • Carcinoma
  • Dystroglycan
  • Epithelial
  • Laminin
  • Mammary

ASJC Scopus subject areas

  • Cancer Research

Cite this

Dystroglycan : Emerging roles in mammary gland function. / Weir, M. Lynn; Muschler, John.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 8, No. 4, 10.2003, p. 409-419.

Research output: Contribution to journalArticle

@article{3538c566560348d0afe03feb79f1cf23,
title = "Dystroglycan: Emerging roles in mammary gland function",
abstract = "Dystroglycan (DG) is a single receptor that binds to multiple basement membrane proteins and forms a transmembrane link to the actin cytoskeleton. It was first isolated as a component of the dystrophin-glycoprotein complex, which plays a role in the maintenance of muscle cell integrity and is defective in many muscular dystrophies. Although studied most extensively in muscle tissues, DG is present at most cell-basement membrane interfaces, and only recently has investigation of DG functions in nonmuscle cells gained momentum. Information emerging from recent studies in epithelial cells is implicating DG in a wide range of critical cell responses to the basement membrane, ranging from organization of tissue architecture to cell survival. Moreover, DG functions appear to be frequently absent in carcinoma cells, implicating its loss in cancer progression. Although many questions remain as to its precise role in mammary tissue, DG is emerging as a potentially important player in mammary gland function.",
keywords = "Breast, Carcinoma, Dystroglycan, Epithelial, Laminin, Mammary",
author = "Weir, {M. Lynn} and John Muschler",
year = "2003",
month = "10",
doi = "10.1023/B:JOMG.0000017428.38034.a7",
language = "English (US)",
volume = "8",
pages = "409--419",
journal = "Journal of Mammary Gland Biology and Neoplasia",
issn = "1083-3021",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Dystroglycan

T2 - Emerging roles in mammary gland function

AU - Weir, M. Lynn

AU - Muschler, John

PY - 2003/10

Y1 - 2003/10

N2 - Dystroglycan (DG) is a single receptor that binds to multiple basement membrane proteins and forms a transmembrane link to the actin cytoskeleton. It was first isolated as a component of the dystrophin-glycoprotein complex, which plays a role in the maintenance of muscle cell integrity and is defective in many muscular dystrophies. Although studied most extensively in muscle tissues, DG is present at most cell-basement membrane interfaces, and only recently has investigation of DG functions in nonmuscle cells gained momentum. Information emerging from recent studies in epithelial cells is implicating DG in a wide range of critical cell responses to the basement membrane, ranging from organization of tissue architecture to cell survival. Moreover, DG functions appear to be frequently absent in carcinoma cells, implicating its loss in cancer progression. Although many questions remain as to its precise role in mammary tissue, DG is emerging as a potentially important player in mammary gland function.

AB - Dystroglycan (DG) is a single receptor that binds to multiple basement membrane proteins and forms a transmembrane link to the actin cytoskeleton. It was first isolated as a component of the dystrophin-glycoprotein complex, which plays a role in the maintenance of muscle cell integrity and is defective in many muscular dystrophies. Although studied most extensively in muscle tissues, DG is present at most cell-basement membrane interfaces, and only recently has investigation of DG functions in nonmuscle cells gained momentum. Information emerging from recent studies in epithelial cells is implicating DG in a wide range of critical cell responses to the basement membrane, ranging from organization of tissue architecture to cell survival. Moreover, DG functions appear to be frequently absent in carcinoma cells, implicating its loss in cancer progression. Although many questions remain as to its precise role in mammary tissue, DG is emerging as a potentially important player in mammary gland function.

KW - Breast

KW - Carcinoma

KW - Dystroglycan

KW - Epithelial

KW - Laminin

KW - Mammary

UR - http://www.scopus.com/inward/record.url?scp=4344637856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344637856&partnerID=8YFLogxK

U2 - 10.1023/B:JOMG.0000017428.38034.a7

DO - 10.1023/B:JOMG.0000017428.38034.a7

M3 - Article

VL - 8

SP - 409

EP - 419

JO - Journal of Mammary Gland Biology and Neoplasia

JF - Journal of Mammary Gland Biology and Neoplasia

SN - 1083-3021

IS - 4

ER -