Dura Mater for Soft-Tissue Augmentation: Evaluation in a Rabbit Model

Michael R. Nordstrom, Tom Wang, H. Bryan Neel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Irradiated human dura mater, a commercially available preparation of dura mater (Tutoplast), and irradiated rabbit dura mater were implanted in subcutaneous pockets in the pinna and forehead of New Zealand white rabbits and evaluated for their usefulness in soft-tissue augmentation at 3 months and 6 months. Postoperatively, no evidence of erythema, purulence, hematoma or seroma formation, wound dehiscence, graft extrusion, or flap necrosis was noted. Irradiated human dura mater was well tolerated by the host and elicited a mild cellular inflammatory response. The graft was well preserved, infiltrated by fibrous connective tissue, and fixed in place in the pinna sites. Forehead grafts were surrounded by a capsule of host tissue and were intact. Dura mater seems to be useful for soft-tissue augmentation. Tutoplast may give good results clinically. Because this represents a short-term evaluation, long-term clinical results are needed to define the potential of dura mater grafts. (Arch Otolaryngol Head Neck Surg. 1993;119:208-214).

Original languageEnglish (US)
Pages (from-to)208-214
Number of pages7
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume119
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Dura Mater
Rabbits
Transplants
Forehead
Seroma
Erythema
Hematoma
Connective Tissue
Capsules
Necrosis
Head
Wounds and Injuries

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Dura Mater for Soft-Tissue Augmentation : Evaluation in a Rabbit Model. / Nordstrom, Michael R.; Wang, Tom; Neel, H. Bryan.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 119, No. 2, 1993, p. 208-214.

Research output: Contribution to journalArticle

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N2 - Irradiated human dura mater, a commercially available preparation of dura mater (Tutoplast), and irradiated rabbit dura mater were implanted in subcutaneous pockets in the pinna and forehead of New Zealand white rabbits and evaluated for their usefulness in soft-tissue augmentation at 3 months and 6 months. Postoperatively, no evidence of erythema, purulence, hematoma or seroma formation, wound dehiscence, graft extrusion, or flap necrosis was noted. Irradiated human dura mater was well tolerated by the host and elicited a mild cellular inflammatory response. The graft was well preserved, infiltrated by fibrous connective tissue, and fixed in place in the pinna sites. Forehead grafts were surrounded by a capsule of host tissue and were intact. Dura mater seems to be useful for soft-tissue augmentation. Tutoplast may give good results clinically. Because this represents a short-term evaluation, long-term clinical results are needed to define the potential of dura mater grafts. (Arch Otolaryngol Head Neck Surg. 1993;119:208-214).

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