Down regulation in B lymphocytes: low dose signals

M. Baltz, Marvin Rittenberg

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Picogram quantities of dinitrophenylated (DNP) dextran, a thymus-independent antigen or lipopolysaccharide, a B cell mitogen, signal down B lymphocytes to unresponsiveness. Down signals were detected by a decision test in which signaled lymphocytes were allowed one hour to react to an immunogenic pulse of DNP-dextran. Depletion of T cells or macrophages did not interfere with the generation of down signals. The signaling can proceed entirely at 4°C and its negative effect is transitory. Down signals which could be detected after 15 min at 37°C were reversed by 60 min. It is suggested that down regulation by low dose antigenic signals provides a means of distinguishing background noise from true antigenic stimuli.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalEuropean Journal of Immunology
Volume7
Issue number4
StatePublished - 1977

Fingerprint

Dextrans
B-Lymphocytes
Down-Regulation
T Independent Antigens
Mitogens
Noise
Macrophages
Lymphocytes
T-Lymphocytes
lipopolysaccharide B

ASJC Scopus subject areas

  • Immunology

Cite this

Baltz, M., & Rittenberg, M. (1977). Down regulation in B lymphocytes: low dose signals. European Journal of Immunology, 7(4), 218-222.

Down regulation in B lymphocytes : low dose signals. / Baltz, M.; Rittenberg, Marvin.

In: European Journal of Immunology, Vol. 7, No. 4, 1977, p. 218-222.

Research output: Contribution to journalArticle

Baltz, M & Rittenberg, M 1977, 'Down regulation in B lymphocytes: low dose signals', European Journal of Immunology, vol. 7, no. 4, pp. 218-222.
Baltz, M. ; Rittenberg, Marvin. / Down regulation in B lymphocytes : low dose signals. In: European Journal of Immunology. 1977 ; Vol. 7, No. 4. pp. 218-222.
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