Dose-dependent effects of angiotensin II on the ovine fetal cardiovascular system

Oliver W. Jones, Cecilia Cheung, Robert A. Brace

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The purpose of this experiment was to establish dose-response relationships for the effects of angiotensin II on arterial pressure, venous pressure, heart rate, and blood volume in the ovine fetus. Chronically catheterized fetal sheep at 132 ± 1 (SE) days' gestational age were infused with angiotensin II at 4.8 ± 1.1 (n = 7), 27.7 ± 4.6 (n = 7), 102.2 ± 16.7 (n = 6), or 239.0 ± 30.9 (n = 4) ng/min/kg fetal body weight for 30 minutes. Fetal arterial pressure increased at the three highest doses. Fetal venous pressure, heart rate, and blood volume responded only at 102.2 and 239.0 ng/min/kg. At 239.0 ng/min/kg, arterial pressure increased by 17.7 ± 1.6 mm Hg (p <0.00001), venous pressure increased by 1.5 ± 0.3 mm Hg (p <0.0005), blood volume decreased by 7.8 ± 2.2% (p <0.0001), and heart rate initially decreased by 14 ± 4 beats/min, followed by an increase of 52 ± 17 beats/min from control (p <0.0005) at the end of angiotensin II infusion. Thus this study shows that angiotensin II affected multiple fetal cardiovascular variables in a dose-dependent manner, suggesting that it is an important regulatory hormone for the entire fetal cardiovascular system.

Original languageEnglish (US)
Pages (from-to)1524-1533
Number of pages10
JournalAmerican Journal of Obstetrics and Gynecology
Volume165
Issue number5 PART 1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Cardiovascular System
Angiotensin II
Venous Pressure
Sheep
Blood Volume
Cardiac Volume
Arterial Pressure
Heart Rate
Fetal Weight
Gestational Age
Fetus
Hormones

Keywords

  • angiotensin II
  • arterial pressure
  • blood volume
  • heart rate
  • Ovine fetus
  • venous pressure

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Dose-dependent effects of angiotensin II on the ovine fetal cardiovascular system. / Jones, Oliver W.; Cheung, Cecilia; Brace, Robert A.

In: American Journal of Obstetrics and Gynecology, Vol. 165, No. 5 PART 1, 1991, p. 1524-1533.

Research output: Contribution to journalArticle

Jones, Oliver W. ; Cheung, Cecilia ; Brace, Robert A. / Dose-dependent effects of angiotensin II on the ovine fetal cardiovascular system. In: American Journal of Obstetrics and Gynecology. 1991 ; Vol. 165, No. 5 PART 1. pp. 1524-1533.
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