Dopamine depletion alters responses to glutamate and GABA in the rat subthalamic nucleus

Ke-Zhong Shen; Steven Johnson

doi:10.1097/00001756-200502080-00021

Dopamine depletion alters responses to glutamate and GABA in the rat subthalamic nucleus

Ke-Zhong Shen, Steven Johnson

Neurology

Research output: Contribution to journal › Article

42 Scopus citations

Abstract

We used whole-cell recordings to compare currents evoked by glutamate and GABA receptor agonists in subthalamic nucleus neurons located ipsilateral and contralateral to unilateral 6-hydroxydopamine (6-OHDA) injections into the substantia nigra zona compacta. The ratio of currents evoked by AMPA (0.6 μM) and NMDA (20 μM) was significantly greater in neurons recorded ipsilateral to 6-OHDA lesions compared with the ratio of currents recorded in control (contralateral) neurons. Both the GABA_A agonist isoguvacine (20 μM) and the GABA_B agonist baclofen (10 μM) evoked significantly greater outward currents in subthalamic nucleus neurons ipsilateral to the lesion compared to contralateral neurons. We conclude that chronic dopamine depletion upregulates expression of GABA receptors and shifts the functional expression of ionotropic glutamate receptor subtype from NMDA to AMPA receptors in subthalamic nucleus.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	NeuroReport
Volume	16
Issue number	2
DOIs	https://doi.org/10.1097/00001756-200502080-00021
Publication status	Published - Feb 8 2005

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Keywords

6-OHDA
AMPA
Baclofen
Brain slice
Isoguvacine
NMDA

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Shen, K-Z., & Johnson, S. (2005). Dopamine depletion alters responses to glutamate and GABA in the rat subthalamic nucleus. NeuroReport, 16(2), 171-174. https://doi.org/10.1097/00001756-200502080-00021

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10.1097/00001756-200502080-00021