Dopamine depletion alters responses to glutamate and GABA in the rat subthalamic nucleus

Research output: Contribution to journalArticle

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Abstract

We used whole-cell recordings to compare currents evoked by glutamate and GABA receptor agonists in subthalamic nucleus neurons located ipsilateral and contralateral to unilateral 6-hydroxydopamine (6-OHDA) injections into the substantia nigra zona compacta. The ratio of currents evoked by AMPA (0.6 μM) and NMDA (20 μM) was significantly greater in neurons recorded ipsilateral to 6-OHDA lesions compared with the ratio of currents recorded in control (contralateral) neurons. Both the GABAA agonist isoguvacine (20 μM) and the GABAB agonist baclofen (10 μM) evoked significantly greater outward currents in subthalamic nucleus neurons ipsilateral to the lesion compared to contralateral neurons. We conclude that chronic dopamine depletion upregulates expression of GABA receptors and shifts the functional expression of ionotropic glutamate receptor subtype from NMDA to AMPA receptors in subthalamic nucleus.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalNeuroReport
Volume16
Issue number2
DOIs
StatePublished - Feb 8 2005

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Subthalamic Nucleus
gamma-Aminobutyric Acid
Glutamic Acid
Dopamine
Oxidopamine
Neurons
N-Methylaspartate
GABA-A Receptor Agonists
GABA Agonists
Ionotropic Glutamate Receptors
Baclofen
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
GABA Receptors
AMPA Receptors
Glutamate Receptors
Herpes Zoster
Patch-Clamp Techniques
Up-Regulation
Injections

Keywords

  • 6-OHDA
  • AMPA
  • Baclofen
  • Brain slice
  • Isoguvacine
  • NMDA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dopamine depletion alters responses to glutamate and GABA in the rat subthalamic nucleus. / Shen, Ke-Zhong; Johnson, Steven.

In: NeuroReport, Vol. 16, No. 2, 08.02.2005, p. 171-174.

Research output: Contribution to journalArticle

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