Does the Microbiome Cause B27-related Acute Anterior Uveitis?

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets. Received 31 October 2015; revised 7 January 2016; accepted 8 January 2016; published online 22 March 2016

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalOcular Immunology and Inflammation
Volume24
Issue number4
DOIs
StatePublished - Jul 3 2016

Keywords

  • Ankylosing spondylitis
  • HLA-B27
  • microbiome
  • spondyloarthropathy
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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