Does the Microbiome Cause B27-related Acute Anterior Uveitis?

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalOcular Immunology and Inflammation
DOIs
StateAccepted/In press - Mar 20 2016

Fingerprint

Anterior Uveitis
Microbiota
Dysbiosis
Molecular Mimicry
Bacterial Translocation
HLA-B27 Antigen
Immune System Diseases
T-Lymphocyte Subsets
Regulatory T-Lymphocytes

Keywords

  • Ankylosing spondylitis
  • HLA-B27
  • microbiome
  • spondyloarthropathy
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

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abstract = "The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets.",
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