Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels?

William Harris, James V. Pottala, Dawn L. Thiselton, Stephen A. Varvel, Alison M. Baedke, Thomas D. Dayspring, G. Russell Warnick, Joseph P. McConnell

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Earlier reports indicated that patients with the apolipoprotein APOE ε4 allele responded to fish oil supplementation with a rise in serum low-density lipoprotein cholesterol (LDL-C) compared to ε3 homozygotes. In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Data from 136,701 patients were available to compare lipid biomarker levels across Omega-3 Index categories associated with heart disease risk in all APOE genotypes. We found no adverse interactions between APOE genotype and the Omega-3 Index for LDL-C, LDL particle number, apoB, HDL-C, or triglycerides. However, we did find evidence that ε2 homozygotes lack an association between omega-3 status and LDL-C, apoB, and LDL particle number. In summary, we found no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.

Original languageEnglish (US)
Pages (from-to)526-532
Number of pages7
JournalJournal of Cardiovascular Translational Research
Volume7
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
LDL Cholesterol
Erythrocytes
Genotype
Lipids
Homozygote
Apolipoproteins B
Serum
Biomarkers
Fish Oils
Apolipoproteins
Heart Diseases
Triglycerides
Alleles
oxidized low density lipoprotein

Keywords

  • apoB
  • APOE genotype
  • APOE4
  • Lipids
  • Low-density lipoproteins
  • Omega-3 fatty acids
  • Triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science
  • Medicine(all)

Cite this

Harris, W., Pottala, J. V., Thiselton, D. L., Varvel, S. A., Baedke, A. M., Dayspring, T. D., ... McConnell, J. P. (2014). Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels? Journal of Cardiovascular Translational Research, 7(5), 526-532. https://doi.org/10.1007/s12265-014-9554-8

Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels? / Harris, William; Pottala, James V.; Thiselton, Dawn L.; Varvel, Stephen A.; Baedke, Alison M.; Dayspring, Thomas D.; Warnick, G. Russell; McConnell, Joseph P.

In: Journal of Cardiovascular Translational Research, Vol. 7, No. 5, 2014, p. 526-532.

Research output: Contribution to journalArticle

Harris, W, Pottala, JV, Thiselton, DL, Varvel, SA, Baedke, AM, Dayspring, TD, Warnick, GR & McConnell, JP 2014, 'Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels?', Journal of Cardiovascular Translational Research, vol. 7, no. 5, pp. 526-532. https://doi.org/10.1007/s12265-014-9554-8
Harris, William ; Pottala, James V. ; Thiselton, Dawn L. ; Varvel, Stephen A. ; Baedke, Alison M. ; Dayspring, Thomas D. ; Warnick, G. Russell ; McConnell, Joseph P. / Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels?. In: Journal of Cardiovascular Translational Research. 2014 ; Vol. 7, No. 5. pp. 526-532.
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