Docetaxel and exisulind in hormone-refractory prostate cancer

Christopher W. Ryan, Walter M. Stadler, Nicholas J. Vogelzang

    Research output: Contribution to journalArticlepeer-review

    14 Scopus citations

    Abstract

    Single-agent docetaxel has been shown to produce a significant decrease in prostate-specific antigen (PSA) levels among patients with hormone-refractory prostate cancer (HRPC). A recent study also showed that exisulind, a sulfone metabolite of the nonsteroidal anti-inflammatory drug sulindac, lengthens the median PSA doubling time in men who had increasing PSA levels after radical prostatectomy. Furthermore, exisulind has shown significant antineoplastic activity in prostate cancer cell lines in vitro and in nude mouse xenograft models. Because preclinical studies have suggested synergistic interactions between docetaxel and exisulind, a phase I/II clinical trial combining these agents has been initiated in patients with HRPC. The primary objective of this study is to determine PSA response and measurable disease response rate of the combination therapy; secondary objectives include toxicity assessment and determination of time to disease progression, duration of response, and overall survival. Accrual is ongoing.

    Original languageEnglish (US)
    Pages (from-to)56-61
    Number of pages6
    JournalSeminars in Oncology
    Volume28
    Issue number4 SUPPL. 15
    StatePublished - Jan 1 2001

    ASJC Scopus subject areas

    • Hematology
    • Oncology

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