Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion: An experimental evaluation

Jiri Sklenar, Suad Ismail, Flordeliza S. Villanueva, N. Craig Goodman, William P. Glasheen, Sanjiv Kaul

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background: Although dobutamine echocardiography is being increasingly used to determine the presence of viable myocardium in patients who have undergone successful reperfusion therapy, the physiological basis for such a use has not been clearly defined. Because postischemic myocardium has contractile reserve, we hypothesized that the absolute degree of wall thickening induced by dobutamine during reflow would be directly related to the amount of myocardium that has escaped necrosis. Methods and Results: Three groups of 12 dogs each were studied at baseline and during 2 to 6 hours of coronary artery occlusion and 15 minutes of reperfusion. In group 1 dogs, which did not receive dobutamine during any of these stages, percent wall thickening at these stages was 32±6%, -2±6%, and 5±6%, respectively, and there was no relation between infarct size and percent wall thickening during reflow (r=.20, P=.51). In group 2 dogs, which received 15 μg/kg per minute of dobutamine at all stages, wall thickening at these stages was 40±8%, 0±8%, and 19±10%, respectively, and a good inverse correlation was noted between infarct size and percent wall thickening during reflow (r=-.81, P=.001). In group 3 dogs, in which wall thickening during reflow was measured both before and during infusion of 15 μg/kg per minute of dobutamine, it was 5±8% and 18±14%, respectively, at these stages. Although the correlation between infarct size and percent wall thickening was poor in the absence of dobutamine (r=.36, P=.26), an excellent inverse correlation was noted between the two in the presence of dobutamine (r=-.93, P

Original languageEnglish (US)
Pages (from-to)1502-1512
Number of pages11
JournalCirculation
Volume90
Issue number3
StatePublished - Sep 1994
Externally publishedYes

Fingerprint

Dobutamine
Reperfusion
Echocardiography
Dogs
Myocardium
Coronary Occlusion
Coronary Vessels
Necrosis

Keywords

  • echocardiography
  • myocardium
  • reperfusion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Sklenar, J., Ismail, S., Villanueva, F. S., Goodman, N. C., Glasheen, W. P., & Kaul, S. (1994). Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion: An experimental evaluation. Circulation, 90(3), 1502-1512.

Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion : An experimental evaluation. / Sklenar, Jiri; Ismail, Suad; Villanueva, Flordeliza S.; Goodman, N. Craig; Glasheen, William P.; Kaul, Sanjiv.

In: Circulation, Vol. 90, No. 3, 09.1994, p. 1502-1512.

Research output: Contribution to journalArticle

Sklenar, J, Ismail, S, Villanueva, FS, Goodman, NC, Glasheen, WP & Kaul, S 1994, 'Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion: An experimental evaluation', Circulation, vol. 90, no. 3, pp. 1502-1512.
Sklenar, Jiri ; Ismail, Suad ; Villanueva, Flordeliza S. ; Goodman, N. Craig ; Glasheen, William P. ; Kaul, Sanjiv. / Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion : An experimental evaluation. In: Circulation. 1994 ; Vol. 90, No. 3. pp. 1502-1512.
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