Do genetic and individual risk factors moderate the efficacy of motivational enhancement therapy? Drinking outcomes with an emerging adult sample

Sarah W. Feldstein Ewing, Heather A. Lachance, Angela Bryan, Kent E. Hutchison

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Research indicates that motivational enhancement therapy (MET) helps catalyze reductions in problem drinking among emerging adults. However, moderators of this intervention remain relatively unknown. Therefore, the objectives of this study were: (1) to test whether a single session of MET increased motivation to reduce drinking and drinking outcomes; and (2) to examine whether genetic dopamine D4 receptor L (DRD4 L) and individual personality risk factors (impulsivity and novelty seeking) moderated the effects of the MET. These hypotheses were evaluated by randomly assigning a sample of emerging adult problem drinkers (n = 67) to receive a single session of MET or alcohol education. Follow-up data indicated that only individuals who were low in impulsivity, novelty seeking and/or who had the short DRD4 variable number of tandem repeats genotype evidenced differentially increased behavior change (taking steps toward reducing drinking) following the MET.

Original languageEnglish (US)
Pages (from-to)356-365
Number of pages10
JournalAddiction Biology
Volume14
Issue number3
DOIs
StatePublished - Jul 1 2009

Keywords

  • Alcohol
  • Emerging adults
  • Genetics
  • Impulsivity
  • Motivation enhancement therapy
  • Novelty seeking

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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