Do endogenous excitatory amino acids influence striatal dopamine release?

Bita Moghaddam, Rand J. Gruen

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

In vivo microdialysis techniques were used to examine whether endogenous excitatory amino acids exert a tonic facilitatory influence on striatal dopamine release. Local application of NMDA and non-NMDA antagonists at 10 μM was without an effect on basal dopamine release while 100 μM and 1 mM of these drugs significantly enhanced the release. Our findings do not support the idea that excitatory amino acids have a tonic excitatory effect on striatal dopamine release.

Original languageEnglish (US)
Pages (from-to)329-330
Number of pages2
JournalBrain research
Volume544
Issue number2
DOIs
StatePublished - Mar 29 1991

Keywords

  • Dopamine
  • Excitatory amino acid
  • Microdialysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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