Do endogenous excitatory amino acids influence striatal dopamine release?

Bita Moghaddam, Rand J. Gruen

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

In vivo microdialysis techniques were used to examine whether endogenous excitatory amino acids exert a tonic facilitatory influence on striatal dopamine release. Local application of NMDA and non-NMDA antagonists at 10 μM was without an effect on basal dopamine release while 100 μM and 1 mM of these drugs significantly enhanced the release. Our findings do not support the idea that excitatory amino acids have a tonic excitatory effect on striatal dopamine release.

Original languageEnglish (US)
Pages (from-to)329-330
Number of pages2
JournalBrain Research
Volume544
Issue number2
DOIs
StatePublished - Mar 29 1991
Externally publishedYes

Fingerprint

Corpus Striatum
Excitatory Amino Acids
Dopamine
Microdialysis
N-Methylaspartate
Pharmaceutical Preparations

Keywords

  • Dopamine
  • Excitatory amino acid
  • Microdialysis

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Do endogenous excitatory amino acids influence striatal dopamine release? / Moghaddam, Bita; Gruen, Rand J.

In: Brain Research, Vol. 544, No. 2, 29.03.1991, p. 329-330.

Research output: Contribution to journalArticle

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