DNA sequence of two closely linked human leukocyte interferon genes

Richard M. Lawn, John Adelman, Thomas J. Dull, Mitchell Gross, David Goeddel, Axel Ullrich

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or α type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.

Original languageEnglish (US)
Pages (from-to)1159-1162
Number of pages4
JournalScience
Volume212
Issue number4499
StatePublished - 1981
Externally publishedYes

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Interferon-alpha
Interferons
Genes
Bacteriophage lambda
Genomic Library
Human Genome
Introns
Complementary DNA
Clone Cells

ASJC Scopus subject areas

  • General

Cite this

Lawn, R. M., Adelman, J., Dull, T. J., Gross, M., Goeddel, D., & Ullrich, A. (1981). DNA sequence of two closely linked human leukocyte interferon genes. Science, 212(4499), 1159-1162.

DNA sequence of two closely linked human leukocyte interferon genes. / Lawn, Richard M.; Adelman, John; Dull, Thomas J.; Gross, Mitchell; Goeddel, David; Ullrich, Axel.

In: Science, Vol. 212, No. 4499, 1981, p. 1159-1162.

Research output: Contribution to journalArticle

Lawn, RM, Adelman, J, Dull, TJ, Gross, M, Goeddel, D & Ullrich, A 1981, 'DNA sequence of two closely linked human leukocyte interferon genes', Science, vol. 212, no. 4499, pp. 1159-1162.
Lawn RM, Adelman J, Dull TJ, Gross M, Goeddel D, Ullrich A. DNA sequence of two closely linked human leukocyte interferon genes. Science. 1981;212(4499):1159-1162.
Lawn, Richard M. ; Adelman, John ; Dull, Thomas J. ; Gross, Mitchell ; Goeddel, David ; Ullrich, Axel. / DNA sequence of two closely linked human leukocyte interferon genes. In: Science. 1981 ; Vol. 212, No. 4499. pp. 1159-1162.
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