DNA sequence of two closely linked human leukocyte interferon genes

Richard M. Lawn, John Adelman, Thomas J. Dull, Mitchell Gross, David Goeddel, Axel Ullrich

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or α type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.

Original languageEnglish (US)
Pages (from-to)1159-1162
Number of pages4
JournalScience
Volume212
Issue number4499
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • General

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