DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: A molecular case report

Hiroyuki Yakushiji, Shinsuke Mukai, Shiroh Matsukura, Seiji Sato, Akiomi Ogawa, Eizaburo Sasatomi, Kohji Miyazaki

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A male patient synchronously or metachronously underwent six curative resections after diagnoses of cancers in the rectum, urinary bladder, stomach, colon, liver and lung. Five cancers, excluding early colon cancer, were analyzed for instability in seven microsatellite markers and in transforming growth factor β type II receptor, insulin-like growth factor II receptor and BAX. All analyzed cancers had replication errors and instability in at least one target gene. These results suggest that abnormal DNA mismatch repair system plays a major role in the occurrence of multiple primary cancers in this case. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalCancer Letters
Volume142
Issue number1
DOIs
StatePublished - Jul 19 1999
Externally publishedYes

Keywords

  • DNA mismatch repair deficiency
  • Microsatellite instability
  • Multiple primary cancers
  • Replication error

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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