Abstract
In this review, recent advances in DNA microarray technology and their applications are examined. The many varieties of DNA microarray or DNA chip devices and systems are described along with their methods for fabrication and their use. This includes both high-density microarrays for high-throughput screening applications and lower-density microarrays for various diagnostic applications. The methods for microarray fabrication that are reviewed include various inkjet and microjet deposition or spotting technologies and processes, in situ or on-chip photolithographic oligonucleotide synthesis processes, and electronic DNA probe addressing processes. The DNA microarray hybridization applications reviewed include the important areas of gene expression analysis and genotyping for point mutations, single nucleotide polymorphisms (SNPs), and short tandem repeats (STRs). In addition to the many molecular biological and genomic research uses, this review covers applications of microarray devices and systems for pharmacogenomic research and drug discovery, infectious and genetic disease and cancer diagnostics, and forensic and genetic identification purposes. Additionally, microarray technology being developed and applied to new areas of proteomic and cellular analysis are reviewed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 129-153 |
| Number of pages | 25 |
| Journal | Annual Review of Biomedical Engineering |
| Volume | 4 |
| DOIs | |
| State | Published - Nov 6 2002 |
| Externally published | Yes |
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Keywords
- DNA arrays
- DNA chips
- DNA devices
- DNA hybridization
- DNA microchips
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Biomedical Engineering
Cite this
DNA microarray technology : Devices, systems, and applications. / Heller, Michael (Mike).
In: Annual Review of Biomedical Engineering, Vol. 4, 06.11.2002, p. 129-153.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - DNA microarray technology
T2 - Devices, systems, and applications
AU - Heller, Michael (Mike)
PY - 2002/11/6
Y1 - 2002/11/6
N2 - In this review, recent advances in DNA microarray technology and their applications are examined. The many varieties of DNA microarray or DNA chip devices and systems are described along with their methods for fabrication and their use. This includes both high-density microarrays for high-throughput screening applications and lower-density microarrays for various diagnostic applications. The methods for microarray fabrication that are reviewed include various inkjet and microjet deposition or spotting technologies and processes, in situ or on-chip photolithographic oligonucleotide synthesis processes, and electronic DNA probe addressing processes. The DNA microarray hybridization applications reviewed include the important areas of gene expression analysis and genotyping for point mutations, single nucleotide polymorphisms (SNPs), and short tandem repeats (STRs). In addition to the many molecular biological and genomic research uses, this review covers applications of microarray devices and systems for pharmacogenomic research and drug discovery, infectious and genetic disease and cancer diagnostics, and forensic and genetic identification purposes. Additionally, microarray technology being developed and applied to new areas of proteomic and cellular analysis are reviewed.
AB - In this review, recent advances in DNA microarray technology and their applications are examined. The many varieties of DNA microarray or DNA chip devices and systems are described along with their methods for fabrication and their use. This includes both high-density microarrays for high-throughput screening applications and lower-density microarrays for various diagnostic applications. The methods for microarray fabrication that are reviewed include various inkjet and microjet deposition or spotting technologies and processes, in situ or on-chip photolithographic oligonucleotide synthesis processes, and electronic DNA probe addressing processes. The DNA microarray hybridization applications reviewed include the important areas of gene expression analysis and genotyping for point mutations, single nucleotide polymorphisms (SNPs), and short tandem repeats (STRs). In addition to the many molecular biological and genomic research uses, this review covers applications of microarray devices and systems for pharmacogenomic research and drug discovery, infectious and genetic disease and cancer diagnostics, and forensic and genetic identification purposes. Additionally, microarray technology being developed and applied to new areas of proteomic and cellular analysis are reviewed.
KW - DNA arrays
KW - DNA chips
KW - DNA devices
KW - DNA hybridization
KW - DNA microchips
UR - http://www.scopus.com/inward/record.url?scp=0036405278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036405278&partnerID=8YFLogxK
U2 - 10.1146/annurev.bioeng.4.020702.153438
DO - 10.1146/annurev.bioeng.4.020702.153438
M3 - Review article
VL - 4
SP - 129
EP - 153
JO - Annual Review of Biomedical Engineering
JF - Annual Review of Biomedical Engineering
SN - 1523-9829
ER -