DNA methylation analysis in human cancer

Eileen O'Sullivan, Michael Goggins

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

The functional impact of aberrant DNA methylation and the widespread alterations in DNA methylation in cancer development have led to the development of a variety of methods to characterize the DNA methylation patterns. This chapter critiques and describes the major approaches to analyzing DNA methylation.

Original languageEnglish (US)
Title of host publicationPancreatic Cancer
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages131-156
Number of pages26
ISBN (Print)9781627032865
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume980
ISSN (Print)1064-3745

Keywords

  • 5-Aza-deoxycytidine
  • 5-Hydroxymethylcytosine
  • 5-Methylcytosine
  • Bisulfite
  • CpG island
  • Methylation-specific PCR
  • Methylbinding protein

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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