Diverse synaptic mechanisms generate direction selectivity in the rabbit retina

William Taylor, David I. Vaney

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

The synaptic conductance of the On-Off direction-selective ganglion cells was measured during visual stimulation to determine whether the direction selectivity is a property of the circuitry presynaptic to the ganglion cells or is generated by postsynaptic interaction of excitatory and inhibitory inputs. Three synaptic asymmetries were identified that contribute to the generation of direction-selective responses: (1) a presynaptic mechanism producing stronger excitation in the preferred direction, (2) a presynaptic mechanism producing stronger inhibition in the opposite direction, and (3) postsynaptic interaction of excitation with spatially offset inhibition. Although the on- and off-responses showed the same directional tuning, the off-response was generated by all three mechanisms, whereas the on-response was generated primarily by the two presynaptic mechanisms. The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation.

Original languageEnglish (US)
Pages (from-to)7712-7720
Number of pages9
JournalJournal of Neuroscience
Volume22
Issue number17
StatePublished - Sep 1 2002

Fingerprint

Retina
Rabbits
Ganglia
Photic Stimulation
Direction compound
Neurons

Keywords

  • Dendritic integration
  • Direction selectivity
  • Excitation
  • Ganglion cells
  • Inhibition
  • On- and off-pathways
  • Rabbit retina
  • Synaptic conductance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Diverse synaptic mechanisms generate direction selectivity in the rabbit retina. / Taylor, William; Vaney, David I.

In: Journal of Neuroscience, Vol. 22, No. 17, 01.09.2002, p. 7712-7720.

Research output: Contribution to journalArticle

Taylor, William ; Vaney, David I. / Diverse synaptic mechanisms generate direction selectivity in the rabbit retina. In: Journal of Neuroscience. 2002 ; Vol. 22, No. 17. pp. 7712-7720.
@article{04fa70b727c7438aab4dd4b1bac19d8c,
title = "Diverse synaptic mechanisms generate direction selectivity in the rabbit retina",
abstract = "The synaptic conductance of the On-Off direction-selective ganglion cells was measured during visual stimulation to determine whether the direction selectivity is a property of the circuitry presynaptic to the ganglion cells or is generated by postsynaptic interaction of excitatory and inhibitory inputs. Three synaptic asymmetries were identified that contribute to the generation of direction-selective responses: (1) a presynaptic mechanism producing stronger excitation in the preferred direction, (2) a presynaptic mechanism producing stronger inhibition in the opposite direction, and (3) postsynaptic interaction of excitation with spatially offset inhibition. Although the on- and off-responses showed the same directional tuning, the off-response was generated by all three mechanisms, whereas the on-response was generated primarily by the two presynaptic mechanisms. The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation.",
keywords = "Dendritic integration, Direction selectivity, Excitation, Ganglion cells, Inhibition, On- and off-pathways, Rabbit retina, Synaptic conductance",
author = "William Taylor and Vaney, {David I.}",
year = "2002",
month = "9",
day = "1",
language = "English (US)",
volume = "22",
pages = "7712--7720",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "17",

}

TY - JOUR

T1 - Diverse synaptic mechanisms generate direction selectivity in the rabbit retina

AU - Taylor, William

AU - Vaney, David I.

PY - 2002/9/1

Y1 - 2002/9/1

N2 - The synaptic conductance of the On-Off direction-selective ganglion cells was measured during visual stimulation to determine whether the direction selectivity is a property of the circuitry presynaptic to the ganglion cells or is generated by postsynaptic interaction of excitatory and inhibitory inputs. Three synaptic asymmetries were identified that contribute to the generation of direction-selective responses: (1) a presynaptic mechanism producing stronger excitation in the preferred direction, (2) a presynaptic mechanism producing stronger inhibition in the opposite direction, and (3) postsynaptic interaction of excitation with spatially offset inhibition. Although the on- and off-responses showed the same directional tuning, the off-response was generated by all three mechanisms, whereas the on-response was generated primarily by the two presynaptic mechanisms. The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation.

AB - The synaptic conductance of the On-Off direction-selective ganglion cells was measured during visual stimulation to determine whether the direction selectivity is a property of the circuitry presynaptic to the ganglion cells or is generated by postsynaptic interaction of excitatory and inhibitory inputs. Three synaptic asymmetries were identified that contribute to the generation of direction-selective responses: (1) a presynaptic mechanism producing stronger excitation in the preferred direction, (2) a presynaptic mechanism producing stronger inhibition in the opposite direction, and (3) postsynaptic interaction of excitation with spatially offset inhibition. Although the on- and off-responses showed the same directional tuning, the off-response was generated by all three mechanisms, whereas the on-response was generated primarily by the two presynaptic mechanisms. The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation.

KW - Dendritic integration

KW - Direction selectivity

KW - Excitation

KW - Ganglion cells

KW - Inhibition

KW - On- and off-pathways

KW - Rabbit retina

KW - Synaptic conductance

UR - http://www.scopus.com/inward/record.url?scp=0036758634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036758634&partnerID=8YFLogxK

M3 - Article

C2 - 12196594

AN - SCOPUS:0036758634

VL - 22

SP - 7712

EP - 7720

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 17

ER -