Diverse roles for hyaluronan and hyaluronan receptors in the developing and adult nervous system

Alec Peters, Larry S. Sherman

    Research output: Contribution to journalReview article

    Abstract

    Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a complex signaling molecule that can regulate cell processes in the developing and adult nervous systems. Signaling properties are determined by molecular weight, bound proteins, and signal transduction through specific receptors. HA signaling regulates processes such as proliferation, differentiation, migration, and process extension in a variety of cell types including neural stem cells, neurons, astrocytes, microglia, and oligodendrocyte progenitors. The synthesis and catabolism of HA and the expression of HA receptors are altered in disease and influence neuroinflammation and disease pathogenesis. This review discusses the roles of HA, its synthesis and breakdown, as well as receptor expression in neurodevelopment, nervous system function and disease.

    Original languageEnglish (US)
    Article number5988
    Pages (from-to)1-21
    Number of pages21
    JournalInternational journal of molecular sciences
    Volume21
    Issue number17
    DOIs
    StatePublished - Sep 1 2020

    Keywords

    • Extracellular matrix
    • Hyaluronan
    • Hyaluronic acid
    • Nervous system
    • Neurodevelopment
    • Neurogenesis

    ASJC Scopus subject areas

    • Catalysis
    • Molecular Biology
    • Spectroscopy
    • Computer Science Applications
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry

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