Diuretic therapy

Arohan R. Subramanya, David H. Ellison

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Diuretics are among the most commonly prescribed pharmacologic agents in the world. In this chapter, we provide a clinically focused review of the major classes of diuretics, including the aquaretics, a newer class of agents that enhance the urinary excretion of solute-free water. We review key factors that influence diuretic efficacy, including the mechanisms underlying natriuretic adaptation and resistance. Lastly, we discuss approaches to the treatment of common generalized edematous states, including heart failure, cirrhosis, nephrotic syndrome, and chronic kidney disease.

Original languageEnglish (US)
Title of host publicationCore Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance
PublisherSpringer US
Number of pages31
ISBN (Electronic)9781461437703
ISBN (Print)1461437695, 9781461437697
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Medicine(all)


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