Diuretics are among the most commonly prescribed pharmacologic agents in the world. In this chapter, we provide a clinically focused review of the major classes of diuretics, including the aquaretics, a newer class of agents that enhance the urinary excretion of solute-free water. We review key factors that influence diuretic efficacy, including the mechanisms underlying natriuretic adaptation and resistance. Lastly, we discuss approaches to the treatment of common generalized edematous states, including heart failure, cirrhosis, nephrotic syndrome, and chronic kidney disease.
|Original language||English (US)|
|Title of host publication||Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance|
|Number of pages||31|
|ISBN (Print)||1461437695, 9781461437697|
|State||Published - Nov 1 2013|
ASJC Scopus subject areas