Dissociation of adrenarche and gonadarche in precocious puberty and in isolated hypogonadotropic hypogonadism

D. R. Counts, O. H. Pescovitz, K. M. Barnes, K. D. Hench, G. P. Chrousos, R. J. Sherins, F. Comite, Donald (Lynn) Loriaux, G. B. Cutler

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Adrenarche is a developmental change of the adrenal gland that results in increased secretion of adrenal androgens. This maturational process generally begins several years before activation of the hypothalamic-pituitary-gonadal axis (gonadarche). To study further the relationship between adrenarche and gonadarche, we examined adrenarche in patients with precocious puberty and in patients with isolated hypogonadotropic hypogonadism. Plasma dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, and cortisol were measured basally and during an infusion of ACTH in 50 children with precocious puberty, 5 patient with isolated hypogonadotropic hypogonadism, 7 preadrcanarchal children with constitutional short stature, 44 normal pubertal children, and 40 normal adults. Children with precocious puberty did not have a corresponding advance in the timing of adrenarche. Their basal and ACTH-stimulated adrenal androgen levels were markedly lower than those of normal children matched for pubertal stage (P <0.05) and were only slightly greater than those reported for normal children of the same age. Similarly, patients with isolated hypogonadotropic hypogonadism and delayed puberty had no corresponding delay of adrenarche. Their adrenal androgen levels were appropriate for chronological age. Thus, these data provide further support for the hypothesis that adrenarche and gonadarche are independent maturational events controlled by separate mechanisms.

Original languageEnglish (US)
Pages (from-to)1174-1178
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume64
Issue number6
StatePublished - 1987
Externally publishedYes

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Adrenarche
Precocious Puberty
Hypogonadism
Androgens
Adrenocorticotropic Hormone
Delayed Puberty
Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Androstenedione
Adrenal Glands
Hydrocortisone
Chemical activation
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Counts, D. R., Pescovitz, O. H., Barnes, K. M., Hench, K. D., Chrousos, G. P., Sherins, R. J., ... Cutler, G. B. (1987). Dissociation of adrenarche and gonadarche in precocious puberty and in isolated hypogonadotropic hypogonadism. Journal of Clinical Endocrinology and Metabolism, 64(6), 1174-1178.

Dissociation of adrenarche and gonadarche in precocious puberty and in isolated hypogonadotropic hypogonadism. / Counts, D. R.; Pescovitz, O. H.; Barnes, K. M.; Hench, K. D.; Chrousos, G. P.; Sherins, R. J.; Comite, F.; Loriaux, Donald (Lynn); Cutler, G. B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 64, No. 6, 1987, p. 1174-1178.

Research output: Contribution to journalArticle

Counts, DR, Pescovitz, OH, Barnes, KM, Hench, KD, Chrousos, GP, Sherins, RJ, Comite, F, Loriaux, DL & Cutler, GB 1987, 'Dissociation of adrenarche and gonadarche in precocious puberty and in isolated hypogonadotropic hypogonadism', Journal of Clinical Endocrinology and Metabolism, vol. 64, no. 6, pp. 1174-1178.
Counts, D. R. ; Pescovitz, O. H. ; Barnes, K. M. ; Hench, K. D. ; Chrousos, G. P. ; Sherins, R. J. ; Comite, F. ; Loriaux, Donald (Lynn) ; Cutler, G. B. / Dissociation of adrenarche and gonadarche in precocious puberty and in isolated hypogonadotropic hypogonadism. In: Journal of Clinical Endocrinology and Metabolism. 1987 ; Vol. 64, No. 6. pp. 1174-1178.
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