Discriminating the size and density of objects within tissue: Frequency-domain versus steady-state measurements

Steven Jacques, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Steady-state (SS) optical measurements are simpler and less expensive than frequency-domain (FD) measurements. So why bother with FD? This paper illustrates the advantage obtained by FD vs. SS, using computer simulated experiments. A single shperical object is placed in the center of our model for the human prostate. The object is given a range of sized and values for its incremental absorption ((Delta) (mu) a) above the background medium (bloodless prostate), with the condition that the optical volume (equals object volume X (Delta) (mu) a) remains constant. Simulations of SS measurements and FD measurements using a 3 GHz modulation frequency were conducted and two measurements simulated: the frequency difference ((Delta) P equals phase with object-phase without object) and the relative amplitude (A/A0 equals amplitude with object/amplitude without object). The results show that A/A0 at SS and 3 GHz are very similar in their response to the object size, and the (Delta) P at 3 GHz offered important additional information.

Original languageEnglish (US)
Title of host publicationOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media
Subtitle of host publicationTheory, Human Studies, and Instrumentation
EditorsBritton Chance, Robert R. Alfano
PublisherSPIE
Pages228-239
Number of pages12
Volume2389
ISBN (Electronic)9780819417367
DOIs
StatePublished - May 30 1995
Externally publishedYes
EventOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation - San Jose, United States
Duration: Feb 1 1995Feb 28 1995

Other

OtherOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
CountryUnited States
CitySan Jose
Period2/1/952/28/95

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Jacques, S., & Hielscher, A. H. (1995). Discriminating the size and density of objects within tissue: Frequency-domain versus steady-state measurements. In B. Chance, & R. R. Alfano (Eds.), Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation (Vol. 2389, pp. 228-239). SPIE. https://doi.org/10.1117/12.209971