Discovery of a small-molecule inhibitor of the KIX-KID interaction

Bingbing X. Li, Xiangshu Xiao

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

(Chemical Equation Presented) Are you too small? The small molecule (M W=297) shown here was discovered to be an inhibitor of the KIX-KID interaction by using a novel Renilla luciferase complementation assay. This compound also inhibits CREB-mediated gene transcription in living cells.

Original languageEnglish (US)
Pages (from-to)2721-2724
Number of pages4
JournalChemBioChem
Volume10
Issue number17
DOIs
StatePublished - Nov 23 2009

Fingerprint

Renilla Luciferases
Transcription
Assays
Genes
Cells
Molecules

Keywords

  • CREB
  • Inhibitors
  • Protein complementation
  • Protein-protein interactions
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Discovery of a small-molecule inhibitor of the KIX-KID interaction. / Li, Bingbing X.; Xiao, Xiangshu.

In: ChemBioChem, Vol. 10, No. 17, 23.11.2009, p. 2721-2724.

Research output: Contribution to journalArticle

Li, Bingbing X. ; Xiao, Xiangshu. / Discovery of a small-molecule inhibitor of the KIX-KID interaction. In: ChemBioChem. 2009 ; Vol. 10, No. 17. pp. 2721-2724.
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